现代爱尔兰ABO、RH和JK血型系统概况。

A snapshot of ABO, RH, and JK blood group systems in modern Ireland.

作者信息

Browne Anne, Kinsella Anthony, Keogh Moira, Morris Kieran, Field Stephen

机构信息

Automated Donor Grouping Laboratory Irish Blood Transfusion Service, National Blood Centre Dublin Ireland.

Molecular & Cellular Therapeutics Royal College of Surgeons Ireland Dublin Ireland.

出版信息

Health Sci Rep. 2021 Jun 12;4(2):e292. doi: 10.1002/hsr2.292. eCollection 2021 Jun.

DOI:10.1002/hsr2.292

PMID:34136655

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8196362/

Abstract

OBJECTIVES

This study aimed to capture a snapshot of the Irish population to determine if there had been any changes in the ABO and RH blood group system (BGS) distribution from previous Irish studies and to establish an Irish JK BGS frequency, providing real time donor information to the Irish Blood Transfusion Service (IBTS).

BACKGROUND

Ireland's population is constantly increasing and becoming more diverse, this has potential implications for the IBTS to provide blood with extended phenotypes for certain cohorts of patients.

MATERIALS AND METHODS

All first time blood donors had relevant testing performed in the Automated Donor Grouping (ADG) laboratory using the Beckman Coulter PK7300 analyzer with appropriate antisera by validated methods. All pertinent information and test results were categorized and analyzed.

RESULTS

The number of donors tested was 3427. ABO phenotype: A: 29.82%, B: 12.02%, O: 54.95% and A,B: 3.21%. RHD: 82.26%. RHCE: RR: 17.62%, RR: 2.89%, RR: 13.95%, Rr: 33.35%, Rr: 13.07%, Rr: 1.25%, RR: 0.06%, RR: 0.06%, r'r: 0.55%, r″r: 0.53%, rr: 16.66%. Kidd phenotype: Jk(a + b+): 49.63%, Jk(a-b+): 23.34%, Jk(a + b-): 27.02%.

CONCLUSION

The observed frequencies for the relevant BGSs remained relatively unchanged to the prevalence values expected; however, statistically significant differences between the 2015 study and some of the previous studies were found for ABO distribution. 14.24% of the first time donors were born outside Ireland and statistically significant differences (-value < 0.001) were noted for aspects of the ABO and Rh phenotype distribution for the Irish born donors (BiI) vs those born outside Ireland (BoI).

摘要

目的

本研究旨在对爱尔兰人口情况进行简要描述，以确定ABO和RH血型系统（BGS）的分布与爱尔兰以往研究相比是否有任何变化，并确定爱尔兰JK血型系统的频率，为爱尔兰输血服务局（IBTS）提供实时献血者信息。

背景

爱尔兰人口持续增长且日益多样化，这对IBTS为某些患者群体提供具有扩展血型表型的血液可能产生影响。

材料与方法

所有首次献血者在自动献血者分组（ADG）实验室使用贝克曼库尔特PK7300分析仪及经过验证的方法和适当抗血清进行相关检测。对所有相关信息和检测结果进行分类和分析。

结果

检测的献血者数量为3427人。ABO血型表型：A：29.82%，B：12.02%，O：54.95%，A,B：3.21%。RHD：82.26%。RHCE：RR：17.62%，RR：2.89%，RR：13.95%，Rr：33.35%，Rr：13.07%，Rr：1.25%，RR：0.06%，RR：0.06%，r'r：0.55%，r″r：0.53%，rr：16.66%。基德血型表型：Jk(a + b+)：49.63%，Jk(a - b+)：23.34%，Jk(a + b -)：27.02%。

结论

观察到的相关血型系统频率与预期流行率相比相对保持不变；然而，在ABO分布方面，发现2015年的研究与一些先前研究之间存在统计学显著差异。14.24%的首次献血者出生在爱尔兰境外，在爱尔兰出生的献血者（BiI）与在爱尔兰境外出生的献血者（BoI）的ABO和Rh血型表型分布方面存在统计学显著差异（-值<0.001）。