超声引导高强度聚焦超声消融子宫肌瘤的血管化：一项可行性研究。
Ultrasound-Guided High-Intensity Focused Ultrasound for Devascularization of Uterine Fibroid: A Feasibility Study.
机构信息
Department of Ultrasonography, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Shanghai Med-X Engineering Research Center, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Ultrasound Med Biol. 2021 Sep;47(9):2622-2635. doi: 10.1016/j.ultrasmedbio.2021.05.012. Epub 2021 Jun 16.
This study aimed to establish the feasibility of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for devascularization of uterine fibroids. Ultrasound color Doppler flow imaging (CDFI) and B-mode imaging were used to target fibroid vascularity. The vessels were covered and ablated by high-intensity focused ultrasound spots. In this study, 42 fibroids with a volume of 66.98 ± 4.00 cm were treated. No blood flow was detected by post-treatment CDFI in 40 fibroids. The 6-mo non-perfusion volume rate was 75.23% ± 34.77% (n = 40). The mean shrinkage in fibroid volume was 38.20% and 43.89%, respectively, at 1 and 6 mo after treatment (p < 0.001). The uterine fibroid symptom and quality of life scores were reduced by 9.43% at 1 mo and 26.66% at 6-mo after treatment (p < 0.001). No serious adverse event was observed. This study demonstrates the feasibility of USgHIFU-induced fibroid devascularization, and more studies are required for the evaluation of safety and efficacy.
本研究旨在探讨超声引导高强度聚焦超声（USgHIFU）治疗子宫肌瘤的可行性。采用超声彩色多普勒血流成像（CDFI）和 B 型成像来靶向子宫肌瘤的血管。通过高强度聚焦超声点来覆盖和消融血管。在本研究中，对 42 个体积为 66.98±4.00cm 的肌瘤进行了治疗。在 40 个肌瘤中，治疗后 CDFI 未检测到血流。6 个月无灌注体积率为 75.23%±34.77%（n=40）。治疗后 1 个月和 6 个月，肌瘤体积平均缩小 38.20%和 43.89%（p<0.001）。治疗后 1 个月和 6 个月，子宫肌瘤症状和生活质量评分分别降低了 9.43%和 26.66%（p<0.001）。未观察到严重不良事件。本研究表明 USgHIFU 诱导的肌瘤血管化是可行的，需要进一步研究来评估其安全性和疗效。
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