西红花苷：结构特征、药代动力学和治疗效果的全面综述。
Crocins: A comprehensive review of structural characteristics, pharmacokinetics and therapeutic effects.
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
出版信息
Fitoterapia. 2021 Sep;153:104969. doi: 10.1016/j.fitote.2021.104969. Epub 2021 Jun 18.
Crocins, as a kind of water-soluble carotenoid pigment, are a series of ester compounds formed from crocetin and gentibiose or glucose, and mainly distributed among Crocus sativus L. (CSL), Gardenia jasminoides Ellis. (GJE). Crocins exhibit a wide range of pharmacological effects on neurodegeneration, cardiovascular disease, cerebrovascular disease, depression, liver disease, arthritis, tumor, diabetes, etc. This review systematically discussed the pharmacologic study of crocins in the aspect of structural characteristic and pharmacokinetics, and summarized the mechanism of treating disease. It summarized the abundant research of crocins from 1984 to 2020 based on the above aspects, which provide a reference for the deeply development and application of crocins.
西红花苷，作为一种水溶性类胡萝卜素色素，是由西红花酸和配基二糖或葡萄糖形成的一系列酯类化合物，主要分布于番红花（Crocus sativus L.）和栀子（Gardenia jasminoides Ellis.）中。西红花苷对神经退行性疾病、心血管疾病、脑血管疾病、抑郁症、肝病、关节炎、肿瘤、糖尿病等具有广泛的药理作用。本综述系统地从结构特征和药代动力学方面讨论了西红花苷的药理研究，并总结了其治疗疾病的机制。基于上述方面，总结了 1984 年至 2020 年西红花苷丰富的研究成果，为西红花苷的深入开发和应用提供了参考。
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