Exploring the signature gut and oral microbiome in individuals of specific .

Diagnosis and treatment of various diseases in , the Indian system of medicine, relies on '' phenotyping of individuals into predominantly three constitutions, and . Recent studies propose that microbiome play an integral role in precision medicine. A study of the relationship between - the basis of personalized medicine in and that of gut microbiome, and possible biomarker of an individual's health, would vastly improve precision therapy. Towards this, we analyzed bacterial metagenomes from buccal (oral microbiome) and fecal (gut microbiome) samples of 272 healthy individuals of various predominant . Major bacterial genera from gut microbiome included and while oral microbiome included and . Though the core microbiome was shared across all individuals, we found prakriti specific signatures such as preferential presence of Paraprevotella and Christensenellaceae in vata individuals. A comparison of core gut microbiome of each with a database of 'healthy' microbes identified microbes unique to each with functional roles similar to the physiological characteristics of various as described in . Our findings provide evidence to interventions based on phenotyping and possible microbial biomarkers that can stratify the heterogenous population and aid in precision therapy.