种间嵌合体作为外源器官生产和移植的平台。
Interspecies chimeras as a platform for exogenic organ production and transplantation.
机构信息
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Exp Biol Med (Maywood). 2021 Aug;246(16):1838-1844. doi: 10.1177/15353702211024948. Epub 2021 Jun 24.
Abstract
Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.
摘要
慢性病与相当高的发病率和死亡率有关。因此，需要新的治疗策略。在这里，我们提供了一个简短的综述，概述了同种和异种嵌合体产生的原理和可行性，这些嵌合体有朝一日可能成为器官移植的平台。这些策略还涉及到对科学和伦理问题的考虑。
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本文引用的文献
1
Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos.
Nat Biomed Eng. 2021 Aug;5(8):805-814. doi: 10.1038/s41551-021-00693-1. Epub 2021 Mar 29.
2
Humanized mouse model: a review on preclinical applications for cancer immunotherapy.
Am J Cancer Res. 2020 Dec 1;10(12):4568-4584. eCollection 2020.
3
Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice.
Cell Rep. 2020 May 12;31(6):107626. doi: 10.1016/j.celrep.2020.107626.
4
Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics.
Stem Cell Reports. 2020 Apr 14;14(4):538-540. doi: 10.1016/j.stemcr.2020.03.016.
5
Generation of human endothelium in pig embryos deficient in ETV2.
Nat Biotechnol. 2020 Mar;38(3):297-302. doi: 10.1038/s41587-019-0373-y. Epub 2020 Feb 24.
6
Xenotransplantation: Current Status in Preclinical Research.
Front Immunol. 2020 Jan 23;10:3060. doi: 10.3389/fimmu.2019.03060. eCollection 2019.
7
Time to rethink the law on part-human chimeras.
J Law Biosci. 2019 May 15;6(1):37-50. doi: 10.1093/jlb/lsz005. eCollection 2019 Oct.
8
Interspecies Chimeras and the Generation of Humanized Organs.
Circ Res. 2019 Jan 4;124(1):23-25. doi: 10.1161/CIRCRESAHA.118.314189.
9
Xenotransplantation: Progress Along Paths Uncertain from Models to Application.
ILAR J. 2018 Dec 31;59(3):286-308. doi: 10.1093/ilar/ily015.
10
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Stem Cell Reports. 2018 Oct 9;11(4):988-997. doi: 10.1016/j.stemcr.2018.08.015. Epub 2018 Sep 20.
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