自身免疫中的光敏感性机制。
Mechanisms of Photosensitivity in Autoimmunity.
机构信息
Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Graduate Program in Immunology, Medical School, University of Michigan, Ann Arbor, Michigan, USA.
Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
出版信息
J Invest Dermatol. 2022 Mar;142(3 Pt B):849-856. doi: 10.1016/j.jid.2021.05.007. Epub 2021 Jun 22.
Aberrant responses to UV light frequently lead to the formation of skin lesions and the activation of systemic inflammation in some autoimmune diseases, especially systemic lupus erythematosus. Whereas the effects of UV light on the skin have been studied for decades, only recently have some of the mechanisms that contribute to abnormal responses to UV light in patients with autoimmune diseases been uncovered. This review will discuss the biology of UV in the epidermis and discuss the abnormal epidermal and inflammatory mechanisms that contribute to photosensitivity. Further research is required to fully understand how to normalize UV-mediated inflammation in patients with autoimmune diseases.
异常的紫外线反应常常导致皮肤损伤，并在某些自身免疫性疾病（尤其是系统性红斑狼疮）中引发全身性炎症。尽管人们对紫外线对皮肤的影响进行了数十年的研究，但直到最近才发现一些导致自身免疫性疾病患者对紫外线异常反应的机制。本文将讨论表皮中紫外线的生物学作用，并探讨导致光敏感的异常表皮和炎症机制。还需要进一步的研究才能全面了解如何使自身免疫性疾病患者的紫外线介导的炎症恢复正常。
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