对用乙二醇和氯化铵处理的大鼠的抗尿路结石活性：可能的药物生化及超微结构效应
The antiurolithic activity of on rats treated with ethylene glycol and ammonium chloride: Possible pharmaco-biochemical and ultrastructure effects.
作者信息
ElSawy Naser A, Mosa Osama F
机构信息
Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Al-Sharqia, Egypt.
Public Health Department, Health Sciences College at Lieth, Umm Al-Qura University, Makkah, The Kingdom of Saudi Arabia.
出版信息
Curr Urol. 2021 Jun;15(2):119-125. doi: 10.1097/CU9.0000000000000017. Epub 2021 May 4.
BACKGROUND
() Linn is one of the conventional remedies for urolithiasis. Hence, we tested the potential antiurolithic effect of active extract, in order to rationalize its medicinal use.
MATERIALS AND METHODS
The in vivo study was of male Westar rats receiving lithogenic treatment consisting of two 0.75% ethylene glycol injections with a 1 day interval and then in drinking water given for 3 weeks along with ammonium chloride (NHCl) from the 2nd day to the 7th day.
RESULTS
The active ethanolic extract of treatment (20 mg/kg) reversed toxic changes including loss of body weight gain and appetite, raised serum urea and creatinine levels, and raised blood pressure compared to controls.
CONCLUSIONS
The acquired data thus suggested that showed antiurolithic effects against renal calcium oxalate crystal deposits by combined mechanisms acting on multiple sites through hypoxaliuric, hypocalciuric, and antioxidant effects.
背景
（）Linn是治疗尿石症的传统药物之一。因此，我们测试了其活性提取物的潜在抗尿石作用，以使其药用合理化。
材料与方法
体内研究采用雄性Westar大鼠，给予致石处理，即间隔1天注射两次0.75%乙二醇，然后从第2天至第7天在饮用水中加入氯化铵（NH₄Cl），持续3周。
结果
与对照组相比，（）处理的活性乙醇提取物（20mg/kg）逆转了包括体重增加和食欲丧失、血清尿素和肌酐水平升高以及血压升高等毒性变化。
结论
因此，获得的数据表明，（）通过低草酸尿、低钙尿和抗氧化作用在多个部位发挥联合作用，对肾草酸钙晶体沉积具有抗尿石作用。
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