Garavand Farhad, Jalai-Jivan Mehdi, Assadpour Elham, Jafari Seid Mahdi
Department of Food Chemistry and Technology, Teagasc Food Research Centre, Moorepark, Fermoy, Co., Cork, Ireland.
Department of Food Science and Technology, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Food Chem. 2021 Dec 1;364:130376. doi: 10.1016/j.foodchem.2021.130376. Epub 2021 Jun 16.
Phenolic compounds (phenolics) have received great attention in the food, pharmaceutical and nutraceutical industries due to their health-promoting attributes. However, their extensive use is limited mainly due to their poor water dispersibility and instability under both processing conditions and/or gastrointestinal interactions, affecting their bioavailability/bioaccessibility. Therefore, different nanocarriers have been widely used to encapsulate phenolics and overcome the aforementioned challenges. To the best of our knowledge, besides many research studies, no comprehensive review on encapsulation of phenolics by microemulsions (MEs) and nanoemulsions (NEs) has been published so far. The present study was therefore attempted to review the loading of phenolics into MEs and NEs. In addition, the fundamental characteristics of the developed systems such as stability, encapsulation efficiency, cytotoxicity, bioavailability and releasing rate are also discussed. Both MEs and NEs are proved as appropriate vehicles to encapsulate and protect phenolics which may expand their applications in foods, supplements and pharmaceuticals.
酚类化合物因其促进健康的特性而在食品、制药和营养保健品行业受到了广泛关注。然而，它们的广泛应用主要受到其较差的水分散性以及在加工条件和/或胃肠道相互作用下的不稳定性的限制，这影响了它们的生物利用度/生物可及性。因此，不同的纳米载体已被广泛用于封装酚类化合物并克服上述挑战。据我们所知，除了许多研究之外，目前尚未发表关于微乳液（MEs）和纳米乳液（NEs）对酚类化合物封装的全面综述。因此，本研究试图综述酚类化合物在MEs和NEs中的负载情况。此外，还讨论了所开发体系的基本特性，如稳定性、包封效率、细胞毒性、生物利用度和释放速率。MEs和NEs都被证明是封装和保护酚类化合物的合适载体，这可能会扩大它们在食品、补充剂和制药领域的应用。
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