Piccoli Luca, Ferrari Paolo, Piumatti Giovanni, Jovic Sandra, Rodriguez Blanca Fernandez, Mele Federico, Giacchetto-Sasselli Isabella, Terrot Tatiana, Silacci-Fregni Chiara, Cameroni Elisabetta, Jaconi Stefano, Sprugasci Nicole, Bartha Istvan, Corti Davide, Uguccioni Mariagrazia, Lanzavecchia Antonio, Garzoni Christian, Giannini Olivier, Bernasconi Enos, Elzi Luigia, Albanese Emiliano, Sallusto Federica, Ceschi Alessandro
Humabs BioMed SA, A Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Department of Internal Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Lancet Reg Health Eur. 2021 Feb;1:100013. doi: 10.1016/j.lanepe.2020.100013. Epub 2020 Dec 17.
Hospital healthcare workers (HCW), in particular those involved in the clinical care of COVID-19 cases, are presumably exposed to a higher risk of acquiring the disease than the general population.
Between April 16 and 30, 2020 we conducted a prospective, SARS-CoV-2 seroprevalence study in HCWs in Southern Switzerland. Participants were hospital personnel with varying COVID-19 exposure risk depending on job function and working site. They provided personal information (including age, sex, occupation, and medical history) and self-reported COVID-19 symptoms. Odds ratio (OR) of seropositivity to IgG antibodies was estimated by univariate and multivariate logistic regressions.
Among 4726 participants, IgG antibodies to SARS-CoV-2 were detected in 9.6% of the HCWs. Seropositivity was higher among HCWs working on COVID-19 wards (14.1% (11.9-16.5)) compared to other hospital areas at medium (10.7% (7.6-14.6)) or low risk exposure (7.3% (6.4-8.3)). OR for high vs. medium wards risk exposure was 1.42 (0.91-2.22), = 0.119, and 1.98 (1.55-2.53), <0.001 for high vs. low wards risk exposure. The same was for true for doctors and nurses (10.1% (9.0-11.3)) compared to other employees at medium (7.1% (4.8-10.0)) or low risk exposure (6.6% (5.0-8.4)). OR for high vs. medium profession risk exposure was 1.37 (0.89-2.11), = 0.149, and 1.75 (1.28-2.40), = 0.001 for high vs. low profession risk exposure. Moreover, seropositivity was higher among HCWs who had household exposure to COVID-19 cases compared to those without (18.7% (15.3-22.5) vs. 7.7% (6.9-8.6), OR 2.80 (2.14-3.67), <0.001).
SARS-CoV-2 antibodies are detectable in up to 10% of HCWs from acute care hospitals in a region with high incidence of COVID-19 in the weeks preceding the study. HCWs with exposure to COVID-19 patients have only a slightly higher absolute risk of seropositivity compared to those without, suggesting that the use of PPE and other measures aiming at reducing nosocomial viral transmission are effective. Household contact with known COVID-19 cases represents the highest risk of seropositivity.
Henry Krenter Foundation, Ente Ospedaliero Cantonale and Vir Biotechnology.
医院医护人员（HCW），尤其是那些参与新型冠状病毒肺炎（COVID-19）病例临床护理的人员，感染该疾病的风险可能高于普通人群。
2020年4月16日至30日，我们在瑞士南部的医护人员中开展了一项前瞻性的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）血清流行率研究。参与者为根据工作职能和工作地点而面临不同COVID-19暴露风险的医院工作人员。他们提供了个人信息（包括年龄、性别、职业和病史）以及自我报告的COVID-19症状。通过单因素和多因素逻辑回归估计IgG抗体血清阳性的比值比（OR）。
在4726名参与者中，9.6%的医护人员检测到SARS-CoV-2的IgG抗体。与处于中度（10.7%（7.6 - 14.6））或低度风险暴露（7.3%（6.4 - 8.3））的其他医院区域相比，在COVID-19病房工作的医护人员血清阳性率更高（14.1%（11.9 - 16.5））。高风险病房与中度风险病房暴露相比的OR为1.42（0.91 - 2.22），P = 0.119，高风险病房与低度风险病房暴露相比的OR为1.98（1.55 - 2.53），P < 0.001。医生和护士（10.1%（9.0 - 11.3））与处于中度（7.1%（4.8 - 10.0））或低度风险暴露（6.6%（5.0 - 8.4））的其他员工相比也是如此。高风险职业与中度风险职业暴露相比的OR为1.37（0.89 - 2.11），P = 0.149，高风险职业与低度风险职业暴露相比的OR为1.75（1.28 - 2.40），P = 0.001。此外，与没有家庭接触COVID-19病例的医护人员相比，有家庭接触COVID-19病例的医护人员血清阳性率更高（18.7%（15.3 - 22.5）对7.7%（6.9 - 8.6），OR 2.80（2.14 - 3.67），P < 0.001）。
在研究前几周COVID-19发病率较高的地区，急性护理医院中高达10%的医护人员可检测到SARS-CoV-2抗体。与未接触COVID-19患者的医护人员相比，接触COVID-19患者的医护人员血清阳性的绝对风险仅略高，这表明使用个人防护装备（PPE）和其他旨在减少医院内病毒传播的措施是有效的。与已知COVID-19病例的家庭接触是血清阳性的最高风险因素。
亨利·克伦特基金会、州立医院管理局和Vir生物技术公司。
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