螺旋藻对2型糖尿病的影响：一项系统评价和荟萃分析。
The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis.
作者信息
Hatami Elaheh, Ghalishourani Samira-Sadat, Najafgholizadeh Ameneh, Pourmasoumi Makan, Hadi Amir, Clark Cain C T, Assaroudi Mostafa, Salehi-Sahlabadi Ammar, Joukar Farahnaz, Mansour-Ghanaei Fariborz
机构信息
Department of Exercise Physiology, Sport Medicine Research Center, Sport Sciences Research Institute, Tehran, Iran.
Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
出版信息
J Diabetes Metab Disord. 2021 Mar 2;20(1):883-892. doi: 10.1007/s40200-021-00760-z. eCollection 2021 Jun.
PURPOSE
The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients.
METHODS
PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity
RESULTS
Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (-17.88 mg/dl; 95% CI: -26.99, -8.78; : 25%), triglyceride (-30.99 mg/dl; 95% CI: -45.20, -16.77; : 50%), total-cholesterol (-18.47 mg/dl; 95% CI: -33.54, -3.39; : 73%), LDL-C (-20.04 mg/dl; 95% CI: -34.06, -6.02; : 75%), VLDL (-6.96 mg/dl; 95% CI: -9.71, -4.22; : 33%), in addition to a significant increase in HDL-C (-6.96 mg/dl; 95% CI: -9.71, -4.22; : 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption.
CONCLUSION
The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s40200-021-00760-z.
目的
本研究旨在探讨螺旋藻对2型糖尿病患者血脂和血糖相关指标的影响。
方法
检索了从创刊至2020年8月的PubMed、Scopus、Cochrane图书馆、ISI科学网和谷歌学术。纳入了所有调查螺旋藻补充剂对2型糖尿病患者血糖相关指标和血脂影响的临床试验。采用随机效应模型进行汇总分析，以弥补研究间的异质性。
结果
荟萃分析纳入了8项研究（9个组）。我们发现，服用螺旋藻后，空腹血糖显著降低（-17.88mg/dl；95%CI：-26.99，-8.78；P=0.25%），甘油三酯显著降低（-30.99mg/dl；95%CI：-45.20，-16.77；P=50%），总胆固醇显著降低（-18.47mg/dl；95%CI：-33.54，-3.39；P=73%），低密度脂蛋白胆固醇显著降低（-20.04mg/dl；95%CI：-34.06，-6.02；P=75%），极低密度脂蛋白显著降低（-6.96mg/dl；95%CI：-9.71，-4.22；P=33%），此外，高密度脂蛋白胆固醇显著升高（-6.96mg/dl；95%CI：-9.71，-4.22；P=33%）。服用螺旋藻后，未观察到对糖化血红蛋白或餐后血糖有显著影响。
结论
本研究表明，补充螺旋藻对空腹血糖和血脂谱有有益影响。
补充信息
在线版本包含可在10.1007/s40200-021-00760-z获取的补充材料。
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