长非编码 RNA HOTAIR 不仅具有抑制作用：在蛋白降解、炎症、DNA 损伤反应和细胞信号转导中。
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling.
机构信息
Gene Regulation and Epigenetics Research Laboratory, Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, 76019, United States.
Gene Regulation and Epigenetics Research Laboratory, Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, 76019, United States.
出版信息
DNA Repair (Amst). 2021 Sep;105:103141. doi: 10.1016/j.dnarep.2021.103141. Epub 2021 Jun 2.
Long noncoding RNAs (lncRNAs) are pervasively transcribed from the mammalian genome as transcripts that are usually >200 nucleotides long. LncRNAs generally do not encode proteins but are involved in a variety of physiological processes, principally as epigenetic regulators. HOX transcript antisense intergenic RNA (HOTAIR) is a well-characterized lncRNA that has been implicated in several cancers and in various other diseases. HOTAIR is a repressor lncRNA and regulates various repressive chromatin modifications. However, recent studies have revealed additional functions of HOTAIR in regulation of protein degradation, microRNA (miRNA) sponging, NF-κB activation, inflammation, immune signaling, and DNA damage response. Herein, we have summarized the diverse functions and modes of action of HOTAIR in protein degradation, inflammation, DNA repair, and diseases, beyond its established functions in gene silencing.
长链非编码 RNA（lncRNA）是从哺乳动物基因组中广泛转录而来的，其转录本通常 >200 个核苷酸长。lncRNA 通常不编码蛋白质，但参与多种生理过程，主要作为表观遗传调节剂。HOX 转录反义基因间 RNA（HOTAIR）是一种特征明确的 lncRNA，已被牵连到多种癌症和其他各种疾病中。HOTAIR 是一种抑制性 lncRNA，调节各种抑制性染色质修饰。然而，最近的研究揭示了 HOTAIR 在蛋白质降解、microRNA（miRNA）海绵、NF-κB 激活、炎症、免疫信号和 DNA 损伤反应中的额外功能。在此，我们总结了 HOTAIR 在蛋白质降解、炎症、DNA 修复和疾病中的多种功能和作用模式，超出了其在基因沉默方面的既定功能。
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