小茴香对原发性痛经的影响：一项系统评价与荟萃分析

Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis.

作者信息

Shahrahmani Hadis, Ghazanfarpour Masumeh, Shahrahmani Nasim, Abdi Fatemeh, Sewell Robert D E, Rafieian-Kopaei Mahmoud

机构信息

Student Research Committee, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Midwifery and Reproductive Health, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

J Complement Integr Med. 2021 Jan 11;18(2):261-269. doi: 10.1515/jcim-2019-0212.

DOI:10.1515/jcim-2019-0212

PMID:34187122

Abstract

BACKGROUND

One of the most common complaints for women is dysmenorrhea. Several studies investigated the treatment effects of medicinal plants on primary dysmenorrhea.

OBJECTIVES

This systematic review and meta-analysis investigates the effect of (Fennel) on pain in primary dysmenorrhea in comparison to non-steroidal anti-inflammatory drugs such as mefenamic acid.

METHODS

PubMed, EMBASE, EBSCO Web of Science, Scopus, Cochrane library, Cochrane Central Register of Controlled Trials (CENTRAL), Science Direct, ProQuest, ISI Web of Science, Google Scholar, Magiran, SID, Iran Medex, and Irandoc were searched up to January 2019. Quality assessment of clinical trials was conducted using Jadad scoring system. Totally, 12 studies were entered in the meta-analysis. was calculated to determine heterogeneity. Fixed effects and/or random effects models were applied.

RESULTS

Meta-analysis of these trials showed that intake decreased significantly the intensity of dysmenorrhea compared to the placebo (SMD -0.632; CI: -0.827 to -0.436; p<0.001; heterogeneity p=0.807; =0%; fixed effect model; seven articles). However, the effect of Mefenamic acid with was not different from each other (SMD=-0.214; CI: -0.446 to 0.017; p=0.07; heterogeneity p=0.58; =0%; fixed effect model; six trials).

CONCLUSION

The alleviates dysmenorrhea. Regarding the same effect of with NSAIDs, it is highly recommend to the women suffered from dysmenorrhea specifically the ones who have high tendency toward herbal medicine.

摘要

背景

痛经是女性最常见的主诉之一。多项研究调查了药用植物对原发性痛经的治疗效果。

目的

本系统评价和荟萃分析旨在研究小茴香与甲芬那酸等非甾体抗炎药相比，对原发性痛经疼痛的影响。

方法

检索了截至2019年1月的PubMed、EMBASE、EBSCO科学网、Scopus、Cochrane图书馆、Cochrane对照试验中央注册库（CENTRAL）、Science Direct、ProQuest、ISI科学网、谷歌学术、Magiran、SID、伊朗医学数据库和伊朗文献数据库。使用Jadad评分系统对临床试验进行质量评估。总共12项研究纳入荟萃分析。计算I²以确定异质性。应用固定效应和/或随机效应模型。

结果

这些试验的荟萃分析表明，与安慰剂相比，摄入小茴香显著降低了痛经强度（标准化均数差-0.632；可信区间：-0.827至-0.436；p<0.001；异质性p=0.807；I²=0%；固定效应模型；7篇文章）。然而，甲芬那酸与小茴香的效果没有差异（标准化均数差=-0.214；可信区间：-0.446至0.017；p=0.07；异质性p=0.58；I²=0%；固定效应模型；6项试验）。