拉丁裔老年人健康与衰老大脑（HABLE）研究方法及参与者特征。
The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics.
作者信息
O'Bryant Sid E, Johnson Leigh A, Barber Robert C, Braskie Meredith N, Christian Bradley, Hall James R, Hazra Nalini, King Kevin, Kothapalli Deydeep, Large Stephanie, Mason David, Matsiyevskiy Elizabeth, McColl Roderick, Nandy Rajesh, Palmer Raymond, Petersen Melissa, Philips Nicole, Rissman Robert A, Shi Yonggang, Toga Arthur W, Vintimilla Raul, Vig Rocky, Zhang Fan, Yaffe Kristine
机构信息
Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Department of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth Texas USA.
出版信息
Alzheimers Dement (Amst). 2021 Jun 21;13(1):e12202. doi: 10.1002/dad2.12202. eCollection 2021.
INTRODUCTION
Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.
METHODS
Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.
RESULTS
Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites.
DISCUSSION
The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.
引言
墨西哥裔美国人在阿尔茨海默病（AD）研究中的代表性仍然严重不足。拉丁裔老年人健康与衰老大脑（HABLE）研究旨在填补现有文献中的重要空白。
方法
招募社区居住的墨西哥裔美国人和非西班牙裔白人成年人及老年人（年龄在50岁及以上）。所有参与者都接受了全面评估，包括访谈、功能检查、临床实验室检查、 informant访谈、神经心理学测试以及脑部3T磁共振成像（MRI）。在第二次访视时增加了淀粉样蛋白和tau正电子发射断层扫描（PET）。血样保存在生物样本库中。
结果
对n = 1705名参与者的数据进行了检查。在医学、人口统计学和社会文化因素方面发现了显著的组间差异。墨西哥裔美国人和非西班牙裔白人之间的脑淀粉样蛋白和神经退行性变成像标志物存在显著差异。
讨论
目前的数据为继续开展研究提供了有力支持，这些研究旨在调查不同人群中AD的危险因素和生物标志物。
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