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黑海中地区儿童发作性肌张力障碍。

Childhood dystonic reactions in the middle Black Sea region.

机构信息

Ordu University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric, Neurology, Ordu, Turkey.

出版信息

Medicine (Baltimore). 2021 Jul 2;100(26):e26465. doi: 10.1097/MD.0000000000026465.

Abstract

Acute dystonic reactions are a worrying reason for presentation to the pediatric emergency department and the pediatric neurology clinic in childhood. It must be diagnosed and treated quickly. The aim of this study was to examine the clinical presentations, etiological factors, and prognosis of patients presenting to our regional tertiary pediatric neurology clinic with a diagnosis of acute dystonic reactions in children.Nine pediatric patients who were treated for acute dystonic reactions between May, 2018 and May, 2020 and had adequate follow-up were included in the study. Medical record data were reviewed age, gender, etiology, features of family, treatment, and results.Three of the patients were female and 6 were male. Their average age was 11 years (4-17). All patients were evaluated as a drug-induced acute dystonic reaction. Of the 9 patients, 5 were due to metoclopramide, 3 were due to risperidone, and 1 was due to aripiprazole. It was learned that a similar situation against other drugs developed in the family history of 3 patients. As a treatment, all of them were intramuscularly applied biperiden suitable for their weight and 30 minutes dramatic improvement was observed. Additional dose had to be administered in only 1 case. All cases were discharged for 24 hours. No problem was observed in their follow-up.Drug-induced acute dystonic reaction can be diagnosed and has a clinical picture that completely resolves when effective treatment is applied. However, it should not be forgotten that it can reach life-threatening dimensions clinically.

摘要

急性肌张力障碍反应是儿童在儿科急诊科和儿科神经科就诊的一个令人担忧的原因。必须迅速诊断和治疗。本研究旨在研究在我们的区域三级儿科神经科诊所就诊的患有儿童急性肌张力障碍反应的患者的临床表现、病因因素和预后。

研究纳入了 2018 年 5 月至 2020 年 5 月期间因急性肌张力障碍反应接受治疗且随访充分的 9 例儿科患者。回顾了病历数据,包括年龄、性别、病因、家族特征、治疗和结果。

3 例患者为女性,6 例为男性。他们的平均年龄为 11 岁(4-17 岁)。所有患者均被评估为药物引起的急性肌张力障碍反应。9 例患者中,5 例因甲氧氯普胺、3 例因利培酮、1 例因阿立哌唑引起。了解到 3 例患者的家族史中有类似情况发生。作为治疗方法,他们均接受了适合体重的肌内注射苯海拉明,30 分钟后观察到明显改善。仅在 1 例中需要额外剂量。所有病例均在 24 小时内出院。在随访中未发现问题。

药物引起的急性肌张力障碍反应可以诊断,并且在有效治疗应用时其临床表现可以完全缓解。但是,不应忘记它在临床上可能会达到危及生命的程度。

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