炭疽疫苗接种个体血浆中炭疽致死毒素中和不足与抗体亚类和结构域特异性相关。
Insufficient Anthrax Lethal Toxin Neutralization Is Associated with Antibody Subclass and Domain Specificity in the Plasma of Anthrax-Vaccinated Individuals.
作者信息
Smith Kenneth, Garman Lori, Norris Kathleen, Muther Jennifer, Duke Angie, Engler Renata J M, Nelson Michael R, Collins Limone C, Spooner Christina, Guthridge Carla, James Judith A
机构信息
Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, 825 NE 13th St., Oklahoma City, OK 73104, USA.
Department of Genes and Human Disease, Oklahoma Medical Research Foundation, 825 NE 13th St., Oklahoma City, OK 73104, USA.
出版信息
Microorganisms. 2021 Jun 2;9(6):1204. doi: 10.3390/microorganisms9061204.
Anthrax vaccine adsorbed (AVA) is a significant line of defense against bioterrorist attack from spores. However, in a subset of individuals, this vaccine may produce a suboptimal quantity of anti-protective antigen (PA), antibodies that are poorly neutralizing, and/or antibody titers that wane over time, necessitating annual boosters. To study individuals with such poor responses, we examine the properties of anti-PA in a subset of vaccinated individuals that make significant quantities of antibody but are still unable to neutralize toxin. In this cohort, characterized by poorly neutralizing antibody, we find that increased IgG4 to IgG1 subclass ratios, low antibody avidity, and insufficient antibody targeting domain 4 associate with improper neutralization. Thus, future vaccines and vaccination schedules should be formulated to improve these deficiencies.
吸附炭疽疫苗（AVA）是抵御孢子生物恐怖袭击的重要防线。然而，在一部分个体中，这种疫苗可能产生的抗保护性抗原（PA）抗体数量未达最佳、中和能力差，和/或抗体滴度随时间下降，因此需要每年加强接种。为了研究有此类不良反应的个体，我们检测了一部分接种疫苗个体体内抗PA的特性，这些个体能产生大量抗体，但仍无法中和毒素。在这个以中和抗体能力差为特征的队列中，我们发现IgG4与IgG1亚类比例增加、抗体亲和力低以及针对结构域4的抗体不足与中和不当有关。因此，未来应制定疫苗和接种计划以改善这些不足。
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