Yang Bo, Li Mingjie, Wang Shuo, Ross R Paul, Stanton Catherine, Zhao Jianxin, Zhang Hao, Chen Wei
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Foods. 2021 Jun 11;10(6):1349. doi: 10.3390/foods10061349.
can stimulate the immune response in vitro, but previous studies were only carried out in vitro and the anti-inflammatory effects of needs more in vivo evidences. In this study, the immune regulation and potential mechanisms of was investigated in DSS-induced colitis mice. FXJWS27L3 and FXJSW17L1 relieved the symptoms of colitis, including inhibition of colon shortening and colon tissue damage. FXJWS27L3 significantly reduced the pro-inflammatory cytokines IL-1β, TNF-α, and IL-17, while FXJSW17L1 significantly increased short chain fatty acids in mice feces. Moreover, FXJWS27L3 and FXJSW17L1 treatments significantly increased the gut microbiota diversity and balance the intestine microbiota profiles, which improved the imbalance of intestine microbiota composition to a certain extent. The results showed that can alleviate DSS-induced colitis, which possibly was related to promoting the expression of pro-inflammatory cytokines, up-regulating SCFAs and restoring the imbalance of gut microbiota.
可在体外刺激免疫反应，但先前的研究仅在体外进行，其抗炎作用需要更多体内证据。在本研究中，在DSS诱导的结肠炎小鼠中研究了其免疫调节和潜在机制。FXJWS27L3和FXJSW17L1缓解了结肠炎症状，包括抑制结肠缩短和结肠组织损伤。FXJWS27L3显著降低促炎细胞因子IL-1β、TNF-α和IL-17，而FXJSW17L1显著增加小鼠粪便中的短链脂肪酸。此外，FXJWS27L3和FXJSW17L1处理显著增加肠道微生物群多样性并平衡肠道微生物群谱，在一定程度上改善了肠道微生物群组成的失衡。结果表明，可减轻DSS诱导的结肠炎，这可能与促进促炎细胞因子表达、上调短链脂肪酸和恢复肠道微生物群失衡有关。
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