将解磷定局部注入中脑网状结构对乙酰胆碱酯酶抑制诱导的海马θ节律的影响。
Effects of pralidoxime applied locally into the midbrain reticular formation on the hippocampal theta rhythm induced by acetylcholinesterase inhibition.
作者信息
Kowalczyk M
机构信息
Department of Pharmacology, Military Institute of Hygiene and Epidemiology, Warsaw.
出版信息
Acta Physiol Pol. 1988 Jan-Feb;39(1):46-50.
PMID:3421136
Abstract
After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. This result suggests that cholinergic structures are localized in midbrain reticular formation and that they play a role in the origin of hippocampal theta rhythm.
摘要
将乙酰胆碱酯酶复活剂——解磷定局部注入中脑网状结构后，在10分钟后就已观察到，先前由二异丙基氟磷酸酯抑制乙酰胆碱酯酶所诱导的海马θ节律强度显著降低。这一结果表明，胆碱能结构定位于中脑网状结构，并且它们在海马θ节律的起源中发挥作用。
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