Department of Medicinal Chemistry, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia.
Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia.
Biomed Res Int. 2021 Jun 7;2021:6656406. doi: 10.1155/2021/6656406. eCollection 2021.
Erectile dysfunction has remained as one of the major global health issues. Since the discovery of phosphodiesterase type 5 inhibitors, a significant portion of the patients has solved the issue of erectile dysfunction. However, the wide distribution of phosphodiesterase type 5 enzymes at various sites of the body led phosphodiesterase type 5 inhibitors to cause various unnecessary outcomes. Hence, it is vital to look for and find optional agents that could solve these limitations. The people of Ethiopia depend heavily on medicinal plants to ease their ailments, including erectile dysfunction. . The current study was carried out to systematically review the traditional medicinal plants used for the management of erectile dysfunction in Ethiopia.
A systematic and manual search was conducted to retrieve relevant articles published from 2000 to August 2020. Electronic databases of PubMed (Medline), Google Scholar, and grey literature were employed to access the studies. Accordingly, fifty-four published articles and thesis papers were finally included in this study.
Seventy plant species have been reported for the management of erectile dysfunction in Ethiopia. The commonly recorded family was Fabaceae, followed by Asteraceae, Malvaceae, Convolvulaceae, and Solanaceae. The plant species that represented the highest number of citations were , succeeded by and . The commonest plant part used was roots. Majority of the medicinal plants were administered orally. The growth forms of the reported species were primarily herbs followed by shrubs.
The present review compiled medicinal plants utilized by the Ethiopian community to manage erectile dysfunction. The findings will serve as a reference for the selection of plants for further pharmacological, toxicological, and phytochemical investigations in developing new plant-based drugs used for the treatment of erectile dysfunction.
勃起功能障碍仍然是全球主要的健康问题之一。自从发现磷酸二酯酶 5 抑制剂以来，相当一部分患者已经解决了勃起功能障碍的问题。然而，磷酸二酯酶 5 酶在体内的各个部位广泛分布，导致磷酸二酯酶 5 抑制剂产生各种不必要的结果。因此，寻找和发现能够解决这些局限性的可选药物是至关重要的。埃塞俄比亚人民严重依赖药用植物来缓解各种疾病，包括勃起功能障碍。本研究旨在系统地回顾用于治疗埃塞俄比亚勃起功能障碍的传统药用植物。
系统和手动搜索从 2000 年到 2020 年 8 月发表的相关文章。使用 PubMed（Medline）、Google Scholar 和灰色文献的电子数据库来获取研究。因此，最终有 54 篇已发表的文章和论文被纳入本研究。
在埃塞俄比亚，有 70 种植物被报道用于治疗勃起功能障碍。记录最常见的科是豆科，其次是菊科、锦葵科、旋花科和茄科。引用次数最高的植物种是，其次是和。最常用的药用植物部位是根。大多数药用植物是口服给药的。所报道的物种的生长形式主要是草本植物，其次是灌木。
本综述汇编了埃塞俄比亚社区用于治疗勃起功能障碍的药用植物。这些发现将为选择植物进行进一步的药理学、毒理学和植物化学研究提供参考，以开发用于治疗勃起功能障碍的新植物药物。
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