长话短说。

The long and short of it.

机构信息

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

出版信息

Elife. 2021 Jul 2;10:e70757. doi: 10.7554/eLife.70757.

DOI:10.7554/eLife.70757

PMID:34213415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8253592/

Abstract

Longer poly(A) tails improve translation in early development, but not in mature cells that have higher levels of the protein PABPC.

摘要

长的 poly(A) 尾巴可以提高早期发育中的翻译效率，但在蛋白质 PABPC 水平较高的成熟细胞中则不然。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8738/8253592/60762088fae0/elife-70757-fig1.jpg

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The long and short of it.长话短说。

Elife. 2021 Jul 2;10:e70757. doi: 10.7554/eLife.70757.

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Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos.胚胎多聚（A）结合蛋白在小鼠卵母细胞和早期胚胎中的表达不同，并与信使 RNA 相互作用。

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Overexpression of poly(A) binding protein prevents maturation-specific deadenylation and translational inactivation in Xenopus oocytes.聚腺苷酸结合蛋白的过表达可防止非洲爪蟾卵母细胞中成熟特异性去腺苷酸化及翻译失活。

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本文引用的文献

The molecular basis of coupling between poly(A)-tail length and translational efficiency.多聚（A）尾长度与翻译效率之间偶联的分子基础。

Elife. 2021 Jul 2;10:e66493. doi: 10.7554/eLife.66493.

FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.FLAM-seq：全长 mRNA 测序揭示 poly(A) 尾长度控制的原则。

Nat Methods. 2019 Sep;16(9):879-886. doi: 10.1038/s41592-019-0503-y. Epub 2019 Aug 5.

Short poly(A) tails are a conserved feature of highly expressed genes.短聚腺苷酸尾巴是高表达基因的一个保守特征。

Nat Struct Mol Biol. 2017 Dec;24(12):1057-1063. doi: 10.1038/nsmb.3499. Epub 2017 Nov 6.

mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome.信使核糖核酸3'端尿苷酸化和聚腺苷酸尾长度塑造哺乳动物母体转录组。

Nature. 2017 Aug 17;548(7667):347-351. doi: 10.1038/nature23318. Epub 2017 Aug 9.

mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development.mTAIL-seq揭示了卵母细胞到胚胎发育过程中动态的多聚腺苷酸尾调控。

Genes Dev. 2016 Jul 15;30(14):1671-82. doi: 10.1101/gad.284802.116. Epub 2016 Jul 21.

Poly(A)-tail profiling reveals an embryonic switch in translational control.多聚（A）尾谱分析揭示了翻译控制中的胚胎转换。

Nature. 2014 Apr 3;508(7494):66-71. doi: 10.1038/nature13007. Epub 2014 Jan 29.

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Globin mRNA species containing poly(A) segments of different lengths. Their functional stability in Xenopus oocytes.含有不同长度聚腺苷酸（poly(A)）片段的珠蛋白信使核糖核酸（mRNA）种类。它们在非洲爪蟾卵母细胞中的功能稳定性。

Eur J Biochem. 1976 Apr 15;64(1):115-21. doi: 10.1111/j.1432-1033.1976.tb10279.x.

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长话短说。

The long and short of it.

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