T 细胞不对称和代谢串扰可以精细调节免疫突触。
T cell asymmetry and metabolic crosstalk can fine-tune immunological synapses.
机构信息
Immunology Service, Hospital Universitario de la Princesa, UAM, IIS-IP. Madrid, 28006, Spain; Area of Vascular Pathophysiology, Laboratory of Intercellular Communication, Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, Madrid, 28029, Spain; Centro de Investigación Básica en Red Cardiovascular, CIBERCV, Madrid, 28029, Spain.
Centro Nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco, Madrid, 28049, Spain.
出版信息
Trends Immunol. 2021 Aug;42(8):649-653. doi: 10.1016/j.it.2021.06.007. Epub 2021 Jul 2.
T cell asymmetry upon specific cell-cell interactions during mammalian immunological synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation and chaperones, such as the eukaryotic chaperonin containing TCP1 (CCT) for protein synthesis and folding. This mechanism can control cytoskeleton dynamics, and regulate mitochondrial fate, respiration, and metabolic rates, ultimately underlying cell reprogramming events that are relevant for CD4 T cell functional outcomes.
T 细胞在哺乳动物免疫突触 (IS) 接触过程中特定的细胞-细胞相互作用时出现不对称性，需要哺乳动物雷帕霉素靶蛋白复合物 (mTORC) 的激活和伴侣分子，如含 TCP1 的真核伴侣素 (CCT)，以进行蛋白质合成和折叠。这种机制可以控制细胞骨架动力学，并调节线粒体命运、呼吸和代谢率，最终为 CD4 T 细胞功能结果的细胞重编程事件提供基础。
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