八种斑马鱼循环水系统中金属和类金属浓度的系统分析。

Division Developmental Biology and Regeneration, Institute of Anatomy, Institute of Geography, University of Bern, Bern, Switzerland.

Laboratory/Soil Science, Institute of Geography, University of Bern, Bern, Switzerland.

Zebrafish. 2021 Aug;18(4):252-264. doi: 10.1089/zeb.2020.1970. Epub 2021 Jul 5.

Metals and metalloids are integral to biological processes and play key roles in physiology and metabolism. Nonetheless, overexposure to some metals or lack of others can lead to serious health consequences. In this study, eight zebrafish facilities collaborated to generate a multielement analysis of their centralized recirculating water systems. We report a first set of average concentrations for 46 elements detected in zebrafish facilities. Our results help to establish an initial baseline for trouble-shooting purposes, and in general for safe ranges of metal concentrations in recirculating water systems, supporting reproducible scientific research outcomes with zebrafish.

金属和类金属是生物过程中不可或缺的一部分，在生理和代谢中发挥着关键作用。然而，过度暴露于某些金属或缺乏某些金属会导致严重的健康后果。在这项研究中，八个斑马鱼设施合作对其集中式循环水系统进行了多元素分析。我们报告了在斑马鱼设施中检测到的 46 种元素的平均浓度的第一组数据。我们的研究结果有助于建立一个用于故障排除的初始基准，通常也有助于确定循环水系统中金属浓度的安全范围，从而支持使用斑马鱼进行可重复的科学研究成果。