尽管使用了脂质体两性霉素 B 预防，白血病患儿仍会发生黄曲霉感染。

Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis.

机构信息

From the Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet.

Department of Clinical Medicine, Copenhagen University, Copenhagen.

出版信息

Pediatr Infect Dis J. 2021 Aug 1;40(8):749-752. doi: 10.1097/INF.0000000000003189.

DOI:10.1097/INF.0000000000003189

PMID:34250973

Abstract

Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.

摘要

两性霉素 B 脂质体（L-AmB）预防治疗用于不能使用唑类药物的白血病患儿，但它的效果存在争议。我们回顾了 2012 年至 2019 年期间，62 例高危白血病患儿每周两次使用 2.5mg/kg L-AmB 后仍发生侵袭性曲霉菌病的病例。10 例（16%）患儿确诊或拟诊为曲霉菌病。因此，L-AmB 预防治疗对曲霉菌，特别是黄曲霉菌，不能提供充分的保护。