Laboratory of Molecular Neurobiology, Department of Genetics and Developmental Biology, Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Adv Exp Med Biol. 2021;1208:191-264. doi: 10.1007/978-981-16-2830-6_11.
Social and economic impacts of neurodegenerative diseases (NDs) become more prominent in our constantly aging population. Currently, due to the lack of knowledge about the aetiology of most NDs, only symptomatic treatment is available for patients. Hence, researchers and clinicians are in need of solid studies on pathological mechanisms of NDs. Autophagy promotes degradation of pathogenic proteins in NDs, while microRNAs post-transcriptionally regulate multiple signalling networks including autophagy. This chapter will critically discuss current research advancements in the area of microRNAs regulating autophagy in NDs. Moreover, we will introduce basic strategies and techniques used in microRNA research. Delineation of the mechanisms contributing to NDs will result in development of better approaches for their early diagnosis and effective treatment.
神经退行性疾病（NDs）在不断老龄化的人口中产生了更显著的社会和经济影响。目前，由于对大多数 NDs 的病因缺乏了解，患者只能接受对症治疗。因此，研究人员和临床医生需要对 NDs 的病理机制进行深入研究。自噬可促进 NDs 中致病性蛋白的降解，而 microRNAs 则在后转录水平上调节包括自噬在内的多种信号网络。本章将批判性地讨论 microRNAs 调控 NDs 中自噬的当前研究进展。此外，我们将介绍 microRNA 研究中使用的基本策略和技术。阐明导致 NDs 的机制将为其早期诊断和有效治疗开发出更好的方法。
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