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他汀类药物治疗前列腺癌:何时用,用多少?

Statins for Prostate Cancer: When and How Much?

机构信息

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Department of Urology, TAYS Cancer Center, Tampere University Hospital, Tampere, Finland.

出版信息

Clin Cancer Res. 2021 Sep 15;27(18):4947-4949. doi: 10.1158/1078-0432.CCR-21-1891. Epub 2021 Jul 19.

Abstract

Statins have plausible biological effects against prostate cancer cells and are associated with improved disease-specific mortality. In current randomized placebo-controlled trial, low-dose atorvastatin caused no difference in relapses after radical prostatectomy in Asian men. Future trials should study higher statin doses at later disease stages with survival as the endpoint..

摘要

他汀类药物对前列腺癌细胞具有合理的生物学作用,并与改善疾病特异性死亡率相关。在目前的随机安慰剂对照试验中,低剂量阿托伐他汀在亚洲男性根治性前列腺切除术后的复发中没有差异。未来的试验应该研究更高剂量的他汀类药物在疾病后期的作用,以生存为终点。

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