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[非阿片类镇痛药的围手术期镇痛:德国疼痛学会、德国麻醉与重症医学学会和德国外科学会基于跨学科共识的联合推荐]

[Perioperative analgesia with nonopioid analgesics : Joint interdisciplinary consensus-based recommendations of the German Pain Society, the German Society of Anaesthesiology and Intensive Care Medicine and the German Society of Surgery].

作者信息

Stamer Ulrike M, Erlenwein Joachim, Freys Stephan M, Stammschulte Thomas, Stichtenoth Dirk, Wirz Stefan

机构信息

Universitätsklinik für Anästhesiologie und Schmerztherapie, Inselspital, Universität Bern, Freiburgstrasse, 3010, Bern, Schweiz.

Arbeitskreis Akutschmerz, Deutsche Schmerzgesellschaft e.V., Berlin, Deutschland.

出版信息

Anaesthesist. 2021 Aug;70(8):689-705. doi: 10.1007/s00101-021-01010-w. Epub 2021 Jul 19.

Abstract

BACKGROUND

Nonopioid analgesics are frequently used for perioperative analgesia; however, insufficient research is available on several practical issues. Often hospitals have no strategy for how to proceed, e.g., for informing patients or for the timing of perioperative administration of nonopioid analgesics.

METHODS

An expert panel representing the German national societies of pain, anaesthesiology and intensive care medicine and surgery developed recommendations for the perioperative use of nonopioid analgesics within a formal, structured consensus process.

RESULTS

The panel agreed that nonopioid analgesics shall be part of a multimodal analgesia concept and that patients have to be informed preoperatively about possible complications and alternative treatment options. Patients' history of pain and analgesic intake shall be evaluated. Patients at risk of severe postoperative pain and possible chronification of postsurgical pain shall be identified. Depending on the duration of surgery, nonopioid analgesics can already be administered preoperatively or intraoperatively so that plasma concentrations are sufficient after emergence from anesthesia. Nonopioid analgesics or combinations of analgesics shall be administered for a limited time only. An interdisciplinary written standard of care, comprising the nonopioid analgesic of choice, possible alternatives, adequate dosing and timing of administration as well as surgery-specific policies, have to be agreed upon by all departments involved. At discharge, the patient's physician shall be informed of analgesics given and those necessary after discharge. Patients shall be informed of possible side effects and symptoms and timely discontinuation of analgesic drugs.

CONCLUSION

The use of nonopioid analgesics as part of a perioperative multimodal concept should be approved and established as an interdisciplinary and interprofessional concept for the adequate treatment of postoperative pain.

摘要

背景

非阿片类镇痛药常用于围手术期镇痛;然而,在几个实际问题上的研究尚不充分。医院通常没有关于如何进行的策略,例如,如何告知患者或非阿片类镇痛药围手术期给药的时机。

方法

一个代表德国疼痛、麻醉学与重症医学以及外科学会的专家小组,在一个正式、结构化的共识过程中制定了非阿片类镇痛药围手术期使用的建议。

结果

专家小组一致认为,非阿片类镇痛药应成为多模式镇痛概念的一部分,并且必须在术前告知患者可能的并发症和替代治疗方案。应评估患者的疼痛史和镇痛药物使用情况。应识别有严重术后疼痛风险和术后疼痛可能慢性化的患者。根据手术时长,非阿片类镇痛药可在术前或术中给药,以便麻醉苏醒后血浆浓度足够。非阿片类镇痛药或镇痛药组合仅应在有限时间内给药。所有相关科室必须就一份跨学科的书面护理标准达成一致,该标准包括首选的非阿片类镇痛药、可能的替代药物、适当的给药剂量和时间以及特定手术的策略。出院时,应告知患者的医生所给予的镇痛药以及出院后所需的镇痛药。应告知患者可能的副作用和症状以及镇痛药的及时停用。

结论

将非阿片类镇痛药用作围手术期多模式概念的一部分,应作为一种跨学科和跨专业的概念获得批准并确立,以充分治疗术后疼痛。

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