1-蔗果三糖对老年肌肉减少症患者的益生元作用相关的肌肉量增加
Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.
作者信息
Tominaga Kentaro, Tsuchiya Atsunori, Nakano Oki, Kuroki Yasutoshi, Oka Kentaro, Minemura Ayaka, Matsumoto Asami, Takahashi Motomichi, Kadota Yoshihiro, Tochio Takumi, Niwa Yusuke, Yoshida Tomoaki, Sato Masatoshi, Yokoo Takeshi, Hashimoto Satoru, Yokoyama Junji, Matsuzawa Jun, Fujimori Katsuya, Terai Shuji
机构信息
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Niigata 951-8510, Japan.
Central Research Institute, Miyarisan Pharmaceutical Co., Ltd., Saitama 331-0804, Japan.
出版信息
Biosci Microbiota Food Health. 2021;40(3):150-155. doi: 10.12938/bmfh.2020-063. Epub 2021 Feb 20.
Sarcopenia causes functional disorders and decreases the quality of life. Thus, it has attracted substantial attention in the aging modern world. Dysbiosis of the intestinal microbiota is associated with sarcopenia; however, it remains unclear whether prebiotics change the microbiota composition and result in the subsequent recovery of muscle atrophy in elderly patients with sarcopenia. This study aimed to assess the effects of prebiotics in super-elderly patients with sarcopenia. We analyzed the effects of 1-kestose on the changes in the intestinal microbiota and body composition using a next-generation sequencer and a multi-frequency bioimpedance analysis device. The population was significantly increased in the intestine after 1-kestose administration. In addition, in all six patients after 12 weeks of 1-kestose administration, the skeletal muscle mass index was greater, and the body fat percentage was lower. This is the first study to show that administration of a prebiotic increased the population of in the intestinal microbiota and caused recovery of muscle atrophy in super-elderly patients with sarcopenia.
肌肉减少症会导致功能障碍并降低生活质量。因此，它在老龄化的现代社会中引起了广泛关注。肠道微生物群失调与肌肉减少症有关；然而，益生元是否会改变微生物群组成并导致老年肌肉减少症患者随后的肌肉萎缩恢复尚不清楚。本研究旨在评估益生元对高龄肌肉减少症患者的影响。我们使用下一代测序仪和多频生物电阻抗分析设备分析了蔗果三糖对肠道微生物群变化和身体成分的影响。服用蔗果三糖后，肠道中的 种群显著增加。此外，在所有六名患者服用蔗果三糖12周后，骨骼肌质量指数更高，体脂百分比更低。这是第一项表明服用益生元可增加高龄肌肉减少症患者肠道微生物群中的 种群并导致肌肉萎缩恢复的研究。 （注：原文中“the population was significantly increased in the intestine after 1-kestose administration.”以及“This is the first study to show that administration of a prebiotic increased the population of in the intestinal microbiota”这两处“the population of ”后面缺失具体内容）
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