重要提示：一氧化二氮（NO）可导致功能性维生素 B 缺乏。
Important reminder: nitrous oxide (NO) as a cause of functional vitamin B deficiency.
机构信息
Internal Medicine, Hurley Medical Center, Flint, Michigan, USA.
Internal Medicine, Hurley Medical Center, Flint, Michigan, USA
出版信息
BMJ Case Rep. 2021 Jul 21;14(7):e241414. doi: 10.1136/bcr-2020-241414.
Abstract
A 32-year-old woman who misused multiple substances, including nitrous oxide (NO), sought medical advice after she subacutely developed bilateral lower extremity weakness without a sensory level but with ataxia-her significant other developed similar symptoms with vitamin B deficiency due to NO intake. Laboratory results revealed macrocytic anaemia despite normal B and folate levels, with serum markers pointing towards functional cobalamin deficiency. Spinal MRIs and cerebrospinal fluid analysis were unremarkable. Our patient was treated with vitamin B supplementation with an encouraging response.
摘要
一位 32 岁的女性滥用多种物质，包括一氧化二氮（NO），在亚急性发作双侧下肢无力但无感觉水平且伴有共济失调后寻求医疗建议——她的伴侣因摄入 NO 而出现类似的维生素 B 缺乏症状。实验室结果显示大细胞性贫血，尽管 B 族和叶酸水平正常，但血清标志物指向功能性钴胺素缺乏。脊髓 MRI 和脑脊液分析无明显异常。我们的患者接受了维生素 B 补充治疗，反应令人鼓舞。
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