腔隙性脑梗死患者血清尿酸、胱抑素C及高敏C反应蛋白与认知功能障碍的相关性
Correlation of serum uric acid, cystatin C and high-sensitivity C-reactive protein with cognitive impairment in lacunar cerebral infarction.
作者信息
Wanggong Fenfei, Xiang Jianfeng, Yang Shichen, Zhang Weilan, Tuerganbieke Reziya
机构信息
Department of Neurology, Xinhua Hospital of Ily Kazakh Autonomous Prefecture Ily, Xinjiang Uygur Autonomous Region, China.
Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai City, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):6717-6723. eCollection 2021.
OBJECTIVE
To study the correlation of serum uric acid (UA), cystatin C (Cys-C) and high-sensitivity C-reactive protein (hs-CRP) with cognitive impairment in lacunar cerebral infarction.
METHODS
Total 198 patients with lacunar cerebral infarction were selected and divided into 4 groups according to their cognitive function, with 65 cases in the normal group, 72 cases in the mild cognitive impairment group, 38 cases in the moderate cognitive impairment group and 23 cases in the severe cognitive impairment group. The hs-CRP, serum UA, Cys-C and Montreal Cognitive Assessment (MoCA) were measured upon admission.
RESULTS
There were statistical differences in hs-CRP, UA and Cys-C among the four groups (all P<0.001). MoCA was negatively correlated with hs-CRP, UA and Cys-C (all P<0.001). Multivariate logistic regression analysis showed that elevated levels of hs-CRP, UA and Cys-C were the influencing factors of cognitive impairment in patients with lacunar cerebral infarction (all P<0.05).
CONCLUSION
The levels of hs-CRP, UA and Cys-C in patients with lacunar cerebral infarction increase with the aggravation of cognitive impairment, and high hs-CRP, UA and Cys-C are independent risk factors of cognitive impairment in patients with lacunar cerebral infarction.
目的
研究血清尿酸（UA）、胱抑素C（Cys-C）及高敏C反应蛋白（hs-CRP）与腔隙性脑梗死认知功能障碍的相关性。
方法
选取198例腔隙性脑梗死患者，根据认知功能分为4组，正常组65例，轻度认知功能障碍组72例，中度认知功能障碍组38例，重度认知功能障碍组23例。入院时测定hs-CRP、血清UA、Cys-C及蒙特利尔认知评估量表（MoCA）。
结果
4组患者hs-CRP、UA及Cys-C比较，差异均有统计学意义（均P<0.001）。MoCA与hs-CRP、UA及Cys-C均呈负相关（均P<0.001）。多因素logistic回归分析显示，hs-CRP、UA及Cys-C水平升高是腔隙性脑梗死患者认知功能障碍的影响因素（均P<0.05）。
结论
腔隙性脑梗死患者hs-CRP、UA及Cys-C水平随认知功能障碍加重而升高，hs-CRP、UA及Cys-C升高是腔隙性脑梗死患者认知功能障碍的独立危险因素。
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