维生素 B 作为氧化还原活性辅因子的临床意义。

Clinical implications of vitamin B as redox-active cofactor.

机构信息

Microbiology and System Biology, Netherlands Organization for Applied Scientific Research, The Hague, The Netherlands.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Trends Mol Med. 2021 Oct;27(10):931-934. doi: 10.1016/j.molmed.2021.07.002. Epub 2021 Jul 23.

DOI:10.1016/j.molmed.2021.07.002

PMID:34312076

Abstract

Vitamin B is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B may be clinically used to reduce oxidative stress and preserve cofactor functions.

摘要

维生素 B 是一种含有钴原子的氧化还原活性化合物，钴原子在氧化态之间循环。超氧化物清除会诱导其氧化，从而使蛋氨酸合成酶和甲基丙二酰辅酶 A 变位酶失活，破坏基因表达和能量产生。高剂量的维生素 B 可在临床上用于减少氧化应激并维持辅因子的功能。