在基尔库克，有不良产科史的女性中细小病毒 B19 的血清流行率。

College of Medicine,Tikrit University, Tikrit, Iraq.

College of Veterinary Medicine, Tikrit University, Tikrit, Iraq.

Antiinflamm Antiallergy Agents Med Chem. 2021;20(4):359-366. doi: 10.2174/1871523020666210727142351.

BACKGROUND

In the Iraqi community, abnormal pregnancy forms a major social and psychological health problem. The underlying etiology of this health phenomenon was varied and included sets of infections and autoimmune diseases. Globally human parvovirus 19 infection is common and the infection attributes to bad obstetric outcomes. The global maternal parvovirus B19 remote infection rate was within a range of 13.2% to 97.9%, while the range of acute infection was between 0.5% to 97.9%. In Arab countries, the IgG seroprevalence was from 53.3% to 74%, while IgM seroprevalence range was 2.2% to 84%.

OBJECTIVE

To evaluate the role of ParvovirusB19 as an etiology of bad obstetric outcome in women in Kirkuk, Iraq.

MATERIALS AND METHODS

Descriptive Case Control Study. Women included in the study were recruited from Kirkuk General Hospital and their age ranged from 14 to 48 years. A total of 663 women were included in the study, of them 237 were not pregnant, while 215 were pregnant. Additionally, the study included 211 women with inevitable abortion. Control group (306 women) women with a history of normal pregnancy included (Pregnant= 149; non-pregnant= 157). Clinical and laboratory investigations were conducted on all patients and control groups to exclude other causes. Medical and obstetric data and demographic characteristics were gathered through interviews according to a previously designed questionnaire. ELISA kits were used to determine Parvovirus B19 IgM and IgG antibodies.

RESULTS

The overall parvovirus seroprevalence was 93% and with no significant difference between women with normal (89.5%) and those with abnormal (93.1%) pregnancy outcomes. In addition, parvovirus IgM overall seroprevalence was at56.3%. Furthermore, current parvovirus infection was higher in women with BOH (52.6%) than that in women with normal pregnancy (49.7%) outcomes. Parvovirus IgM seroprevalence was 52.6% in women with BOH and 49.7% in women with normal pregnancy, however, the difference was not statistically significant. In contrast, the acute infection with parvovirus was significantly (X2=11.8, P=0.001) lower in women with normal pregnancy (49.7%) than in those with inevitable abortion (64.9%). While the IgG seroprevalence difference was not significant between the two groups, infection seroprevalence was more frequent in housewives, uneducated women, large families, non-smokers, in rural areas, non-animal exposure areas, women with repeated abortion, congenital anomalies and anaemia.

CONCLUSION

Parvovirus B19 infection may be with bad obstetric outcomes if occurred during pregnancy and OR confirmed a significant association of the infection with parvovirus with smoking, occupation, crowding index, education, animal exposure and the number of repeated abortion.

背景

在伊拉克社区，异常妊娠是一个主要的社会和心理健康问题。这种健康现象的潜在病因多种多样，包括一系列感染和自身免疫性疾病。全球人类细小病毒 19 感染很常见，这种感染会导致不良的产科结局。全球产妇细小病毒 B19 远程感染率在 13.2%至 97.9%之间，而急性感染率在 0.5%至 97.9%之间。在阿拉伯国家，IgG 血清阳性率为 53.3%至 74%，而 IgM 血清阳性率范围为 2.2%至 84%。

目的

评估细小病毒 B19 在伊拉克基尔库克妇女不良产科结局中的病因作用。

材料和方法

描述性病例对照研究。研究纳入的妇女来自基尔库克综合医院，年龄在 14 至 48 岁之间。共有 663 名妇女被纳入研究，其中 237 名未怀孕，215 名怀孕。此外，研究还包括 211 名难免流产的妇女。对照组（306 名）包括有正常妊娠史的妇女（妊娠=149；未妊娠=157）。对所有患者和对照组进行临床和实验室检查，以排除其他原因。通过事先设计的问卷，通过访谈收集医疗和产科数据以及人口统计学特征。使用 ELISA 试剂盒检测细小病毒 B19 IgM 和 IgG 抗体。

结果

总体细小病毒血清阳性率为 93%，正常妊娠（89.5%）和异常妊娠（93.1%）妇女之间无显著差异。此外，细小病毒 IgM 总血清阳性率为 56.3%。此外，BOH 妇女的当前细小病毒感染率（52.6%）高于正常妊娠（49.7%）妇女。BOH 妇女的细小病毒 IgM 血清阳性率为 52.6%，正常妊娠妇女为 49.7%，但差异无统计学意义。相比之下，正常妊娠妇女（49.7%）细小病毒急性感染明显低于难免流产妇女（64.9%）（X2=11.8，P=0.001）。虽然两组 IgG 血清阳性率无显著差异，但感染血清阳性率在家庭主妇、未受教育妇女、大家庭、不吸烟者、农村地区、无动物接触地区、反复流产、先天畸形和贫血妇女中更为常见。