School of Bioengineering, Dalian Polytechnic University, Dalian 116034, Liaoning Province, China.
World J Gastroenterol. 2021 Jul 7;27(25):3837-3850. doi: 10.3748/wjg.v27.i25.3837.
Obesity is a major global health problem determined by heredity and environment, and its incidence is increasing yearly. In recent years, increasing evidence linking obesity to the gut microbiota has been reported. Gut microbiota management has become a new method of obesity treatment. However, the complex interactions among genetics, environment, the gut microbiota, and obesity remain poorly understood. In this review, we summarize the characteristics of the gut microbiota in obesity, the mechanism of obesity induced by the gut microbiota, and the influence of genetic and environmental factors on the gut microbiota and obesity to provide support for understanding the complex relationship between obesity and microbiota. At the same time, the prospect of obesity research related to the gut microbiota is proposed.
肥胖是由遗传和环境决定的一个主要全球健康问题,其发病率逐年上升。近年来,越来越多的证据表明肥胖与肠道微生物群有关。肠道微生物群管理已成为一种新的肥胖治疗方法。然而,遗传、环境、肠道微生物群和肥胖之间的复杂相互作用仍知之甚少。在这篇综述中,我们总结了肥胖症肠道微生物群的特征、肠道微生物群引起肥胖的机制,以及遗传和环境因素对肠道微生物群和肥胖的影响,为理解肥胖与微生物群之间的复杂关系提供支持。同时,提出了与肠道微生物群相关的肥胖研究前景。