T 细胞指导小胶质细胞对中风后白质进行修复。
T cells direct microglial repair of white matter after stroke.
机构信息
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
出版信息
Trends Neurosci. 2021 Oct;44(10):769-770. doi: 10.1016/j.tins.2021.07.005. Epub 2021 Jul 28.
A recent paper by Shi et al. defines the role of regulatory T cells (Tregs) in white matter recovery after ischemic stroke. This study elucidates the mechanisms by which Tregs direct microglia to alter their phenotype to support oligodendrogenesis, thereby improving white matter integrity and functional recovery after stroke in mice.
石等人最近的一篇论文定义了调节性 T 细胞（Tregs）在缺血性中风后白质恢复中的作用。这项研究阐明了 Tregs 指导小胶质细胞改变表型以支持少突胶质细胞发生的机制，从而改善了小鼠中风后白质的完整性和功能恢复。
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