青少年起病的1型糖尿病成年患者的持续性注意力缺陷

Sustained Attention Deficits in Adults With Juvenile-Onset Type 1 Diabetes Mellitus.

作者信息

Zou Wenjing, He Jing, Liu Yuzhuo, Zhu Jiang, Liu Fang, Xie Yuting, Li Chuting, Du Hongyu, Huang Fansu, Zhou Zhiguang, Li Xia, Zhu Xiongzhao

机构信息

From the Medical Psychological Center (Zou, Y. Liu, J. Zhu, C. Li, Du, X. Zhu), The Second Xiangya Hospital, Central South University; Medical Psychological Institute of Central South University (X. Zhu); National Clinical Research Center for Mental Disorders (X. Zhu), The Second Xiangya Hospital; Department of Psychology (He) and Hunan Key Laboratory of Children's Psychological Development and Brain Cognitive Science (He), Hunan First Normal University; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology (Zou, Y. Liu, Xie, Zhou, X. Li), The Second Xiangya Hospital of Central South University; Xiangya School of Nursing (F. Liu), Central South University, Hunan Province; and Department of Nutrition (Huang), The Second Xiangya Hospital, Central South University, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan Province, China.

出版信息

Psychosom Med. 2021 Oct 1;83(8):906-912. doi: 10.1097/PSY.0000000000000992.

DOI:10.1097/PSY.0000000000000992

PMID:34334732

Abstract

OBJECTIVE

This study aimed to investigate whether patients with juvenile-onset type 1 diabetes mellitus (T1DM) have poorer sustained attention than their counterparts with adult-onset T1DM, and whether there is a relationship between diabetes-related variables and sustained attention.

METHODS

This study included 76 participants with juvenile-onset T1DM, 68 participants with adult-onset T1DM, and 85 healthy controls (HCs). All participants completed the Sustained Attention to Response Task, Beck Depression Inventory-II, and the Chinese version of the Wechsler Adult Intelligence Scale.

RESULTS

The juvenile-onset group showed more omission errors (p = .007) than the adult-onset group and shorter reaction time (p = .005) than HCs, whereas the adult-onset group showed no significant differences compared with HCs. Hierarchical linear regression analysis revealed that the age of onset was associated with omission errors in T1DM participants (β = -0.275, t = -2.002, p = .047). In the juvenile-onset group, the omission error rate were associated with the history of severe hypoglycemia (β = 0.225, t = 1.996, p = .050), whereas reaction time was associated with the age of onset (β = -0.251, t = -2.271, p = .026). Fasting blood glucose levels were significantly associated with reaction time in both the juvenile-onset and adult-onset groups (β = -0.236, t = -2.117, p = .038, and β = 0.259, t = 2.041, p = .046, respectively).

CONCLUSIONS

Adults with juvenile-onset T1DM have sustained attention deficits in contrast to their adult-onset counterparts, suggesting that the disease adversely affects the developing brain. Both the history of severe hypoglycemia and fasting blood glucose levels are factors associated with sustained attention impairment. Early diagnosis and treatment in juvenile patients are required to prevent the detrimental effects of diabetes.

摘要

目的

本研究旨在调查青少年起病的1型糖尿病（T1DM）患者的持续注意力是否比成人起病的T1DM患者更差，以及糖尿病相关变量与持续注意力之间是否存在关联。

方法

本研究纳入了76名青少年起病的T1DM患者、68名成人起病的T1DM患者和85名健康对照者（HCs）。所有参与者均完成了持续注意力反应任务、贝克抑郁量表第二版以及中文版韦氏成人智力量表。

结果

青少年起病组的漏报错误比成人起病组更多（p = 0.007），反应时间比健康对照者更短（p = 0.005），而成人起病组与健康对照者相比无显著差异。分层线性回归分析显示，起病年龄与T1DM参与者的漏报错误有关（β = -0.275，t = -2.002，p = 0.047）。在青少年起病组中，漏报错误率与严重低血糖病史有关（β = 0.225，t = 1.996，p = 0.050），而反应时间与起病年龄有关（β = -0.251，t = -2.271，p = 0.026）。青少年起病组和成人起病组的空腹血糖水平均与反应时间显著相关（分别为β = -0.236，t = -2.117，p = 0.038；β = 0.259，t = 2.041，p = 0.046）。