Mousavi Seyyed Mojtaba, Hashemi Seyyed Alireza, Mazraedoost Sargol, Yousefi Khadije, Gholami Ahmad, Behbudi Gity, Ramakrishna Seeram, Omidifar Navid, Alizadeh Ali, Chiang Wei-Hung
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10617, Taiwan.
Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada.
Nanomaterials (Basel). 2021 Jul 20;11(7):1868. doi: 10.3390/nano11071868.
Multifunctional gold nanorods (GNR) have drawn growing interest in biomedical fields because of their excellent biocompatibility, ease of alteration, and special optical properties. The great advantage of using GNR in medicine is their application to Photothermal therapy (PPTT), which is possible thanks to their ability to turn luminous energy into heat to cause cellular hyperthermia. For this purpose, the relevant articles between 1988 and 2020 were searched in databases such as John Wiley, Free paper, Scopus, Science Direct, and Springer to obtain the latest findings on multifunctional gold nanorods for therapeutic applications and pharmaceutical delivery. In this article, we review recent progress in diagnostic and therapeutic applications of multifunctional GNR, highlighting new information about their toxicity to various cellular categories, oxidative stress, cellular longevity, and their metabolic effects, such as the effect on the energy cycles and genetic structures. The methods for the synthesis and functionalization of GNR were surveyed. This review includes new information about GNR toxicity to various cellular categories and their metabolic effects.
多功能金纳米棒（GNR）因其出色的生物相容性、易于改性以及特殊的光学性质，在生物医学领域引起了越来越多的关注。在医学中使用GNR的一大优势在于其在光热疗法（PPTT）中的应用，这得益于它们能够将光能转化为热量从而引发细胞热疗。为此，在诸如约翰·威利、免费论文、Scopus、科学Direct和施普林格等数据库中检索了1988年至2020年期间的相关文章，以获取关于多功能金纳米棒用于治疗应用和药物递送的最新研究结果。在本文中，我们综述了多功能GNR在诊断和治疗应用方面的最新进展，重点介绍了有关它们对各种细胞类型的毒性、氧化应激、细胞寿命及其代谢影响（如对能量循环和基因结构的影响）的新信息。还调查了GNR的合成和功能化方法。本综述包括有关GNR对各种细胞类型的毒性及其代谢影响的新信息。
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