尿路上皮癌的分子病理学。
Molecular Pathology of Urothelial Carcinoma.
机构信息
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NW 10065, USA.
Department of Pathology, University of Alabama at Birmingham, University of Alabama at Birmingham School of Medicine, WP Building, Suite P230, 619 19th Street South, Birmingham, AL 35249-7331, USA.
出版信息
Surg Pathol Clin. 2021 Sep;14(3):403-414. doi: 10.1016/j.path.2021.05.005.
Abstract
Urothelial carcinoma is characterized by the presence of a wide spectrum of histopathologic features and molecular alterations that contribute to its morphologic and genomic heterogeneity. It typically harbors high rates of somatic mutations with considerable genomic and transcriptional complexity and heterogeneity that is reflective of its varied histomorphologic and clinical features. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of urothelial carcinoma and variant histologies.
摘要
尿路上皮癌的特征是存在广泛的组织病理学特征和分子改变，这些特征导致其形态学和基因组异质性。它通常具有高比例的体细胞突变，具有相当大的基因组和转录复杂性和异质性，反映了其不同的组织形态学和临床特征。本文综述了尿路上皮癌和变异组织学的分子特征和新型分子分类学的最新进展。
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本文引用的文献
1
Nested Variant of Urothelial Carcinoma Is a Luminal Bladder Tumor With Distinct Coexpression of the Basal Marker Cytokeratin 5/6.
Am J Clin Pathol. 2021 Mar 15;155(4):588-596. doi: 10.1093/ajcp/aqaa160.
2
Macroscopic somatic clonal expansion in morphologically normal human urothelium.
Science. 2020 Oct 2;370(6512):82-89. doi: 10.1126/science.aba7300.
3
Extensive heterogeneity in somatic mutation and selection in the human bladder.
Science. 2020 Oct 2;370(6512):75-82. doi: 10.1126/science.aba8347.
4
Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer.
iScience. 2020 Jun 26;23(6):101201. doi: 10.1016/j.isci.2020.101201. Epub 2020 May 27.
5
Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes.
Nat Rev Urol. 2020 May;17(5):259-270. doi: 10.1038/s41585-020-0304-1. Epub 2020 Mar 31.
6
Pure Large Nested Variant of Urothelial Carcinoma (LNUC) Is the Prototype of an Mutated Aggressive Urothelial Carcinoma with Luminal-Papillary Phenotype.
Cancers (Basel). 2020 Mar 24;12(3):763. doi: 10.3390/cancers12030763.
7
Comparative genomic profiling of glandular bladder tumours.
Virchows Arch. 2020 Sep;477(3):445-454. doi: 10.1007/s00428-020-02787-8. Epub 2020 Mar 20.
8
PAX8 expression and TERT promoter mutations in the nested variant of urothelial carcinoma: a clinicopathologic study with immunohistochemical and molecular correlates.
Mod Pathol. 2020 Jun;33(6):1165-1171. doi: 10.1038/s41379-020-0453-z. Epub 2020 Jan 13.
9
Updates on the Genomics of Bladder Cancer and Novel Molecular Taxonomy.
Adv Anat Pathol. 2020 Jan;27(1):36-43. doi: 10.1097/PAP.0000000000000252.
10
Development of Genome-Derived Tumor Type Prediction to Inform Clinical Cancer Care.
JAMA Oncol. 2020 Jan 1;6(1):84-91. doi: 10.1001/jamaoncol.2019.3985.
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