药师主导的耐甲氧西林鼻聚合酶链反应检测方案用于降低疑似肺炎经验性万古霉素使用剂量的停药模式及成本规避
Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia.
作者信息
Meng L, Pourali S, Hitchcock M M, Ha D R, Mui E, Alegria W, Fox E, Diep C, Swayngim R, Chang A, Banaei N, Deresinski S, Holubar M
机构信息
Department of Quality, Patient Safety and Effectiveness, Stanford Health Care, Stanford, California, USA.
Stanford Antimicrobial Safety and Sustainability Program, Stanford, California, USA.
出版信息
Open Forum Infect Dis. 2021 Mar 4;8(4):ofab099. doi: 10.1093/ofid/ofab099. eCollection 2021 Apr.
A pharmacist-driven methicillin-resistant (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary vancomycin use with an estimated cost avoidance of $40 per vancomycin course. We found high concordance (141 of 147, 96%) of culture-based versus PCR-based MRSA nasal screening.
由药剂师主导的基于耐甲氧西林金黄色葡萄球菌（MRSA）鼻腔聚合酶链反应（PCR）的检测方案，在阴性结果后24小时内停用万古霉素的接受率为70%，显著减少了不必要的万古霉素使用，估计每个万古霉素疗程可节省40美元。我们发现基于培养的MRSA鼻腔筛查与基于PCR的筛查具有高度一致性（147例中的141例，96%）。
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