组织特异性 DNA 修复：CRISPR 指南针。

Tissue specificity of DNA repair: the CRISPR compass.

机构信息

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

出版信息

Trends Genet. 2021 Nov;37(11):958-962. doi: 10.1016/j.tig.2021.07.010. Epub 2021 Aug 12.

DOI:10.1016/j.tig.2021.07.010

PMID:34392967

Abstract

CRISPR-Cas9-mediated genome editing holds great promise for the correction of pathogenic variants in humans. However, its therapeutic implementation is hampered due to unwanted editing outcomes. A better understanding of cell type- and tissue-specific DNA repair processes will ultimately enable precise control of editing outcomes for safer and effective therapies.

摘要

CRISPR-Cas9 介导的基因组编辑技术为纠正人类致病突变提供了巨大的潜力。然而，由于非预期的编辑结果，其治疗应用受到了阻碍。更好地了解细胞类型和组织特异性的 DNA 修复过程，最终将能够精确控制编辑结果，以实现更安全有效的治疗。