Dao Riao, Wu Dongxing, Wang Huan, Jin Habur, Li Li, Fu Xiquan, Sa Chula
Inner Mongolia University for Nationalities, Mongolian Medical College, Tongliao City, Inner Mongolia Autonomous Region 028000, China.
Department of Psychosomatic Medicine, International Mongolian Medical Hospital of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region 010010, China.
Evid Based Complement Alternat Med. 2021 Aug 3;2021:5532069. doi: 10.1155/2021/5532069. eCollection 2021.
Mongolian medicine is a systematic theoretical system, which is based on the balance among Heyi, Xila, and Badagan. However, the underlying mechanisms remain unclear. This study aimed to explore the characteristics of intestinal microbiota and metabolites in different rat models of Mongolian medicine.
After establishing rat models of Heyi, Xila, and Badagan, we integrated 16S rRNA gene sequencing and metabolomics.
Heyi, Xila, and Badagan rats had significantly altered intestinal microbial composition compared with rats in the MCK group. They showed 11, 18, and 8 significantly differential bacterial biomarkers and 22, 11, and 15 differential metabolites, respectively. The glucosinolate biosynthesis pathway was enriched only in Heyi rats; the biosynthesis of phenylpropanoids pathway and phenylpropanoid biosynthesis pathway were enriched only in Xila rats; the isoflavonoid biosynthesis pathway, the glycine, serine, and threonine metabolism pathway, and the arginine and proline metabolism pathway were enriched only in Badagan rats.
The intestinal microbiota, metabolites, and metabolic pathways significantly differed among Heyi, Xila, and Badagan rats compared with control group rats.
蒙医学是一个系统的理论体系，它基于赫依、希拉和巴达干之间的平衡。然而，其潜在机制仍不清楚。本研究旨在探讨蒙医学不同大鼠模型中肠道微生物群和代谢产物的特征。
建立赫依、希拉和巴达干大鼠模型后，我们整合了16S rRNA基因测序和代谢组学。
与MCK组大鼠相比，赫依、希拉和巴达干大鼠的肠道微生物组成有显著改变。它们分别显示出11种、18种和8种显著差异的细菌生物标志物以及22种、11种和15种差异代谢产物。芥子油苷生物合成途径仅在赫依大鼠中富集；苯丙烷类生物合成途径和苯丙素生物合成途径仅在希拉大鼠中富集；异黄酮生物合成途径、甘氨酸、丝氨酸和苏氨酸代谢途径以及精氨酸和脯氨酸代谢途径仅在巴达干大鼠中富集。
与对照组大鼠相比，赫依、希拉和巴达干大鼠的肠道微生物群、代谢产物和代谢途径存在显著差异。
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