超重和血脂异常问题作为 1 型糖尿病患儿和青少年心血管疾病的危险因素。
The Problem of Abnormal Body Weight and Dyslipidemia as Risk Factors for Cardiovascular Diseases in Children and Adolescents with Type 1 Diabetes.
机构信息
Department of Children's Diabetology, Upper Silesian Child Health Centre, Katowice, Poland.
Department of Children's Diabetology, Medical University of Silesia, Katowice, Poland.
出版信息
J Diabetes Res. 2021 Aug 2;2021:5555149. doi: 10.1155/2021/5555149. eCollection 2021.
Diabetes is a disease that affects many people around the world. Its complications are the cause of cardiovascular diseases (CVD) and increased mortality. That is why the search for predictive biomarkers is so important. The aim of the study was to show the prevalence of the problem and risk factors in children and adolescents with type 1 diabetes. These patients are often overweight and obese, and the percentage of lipid disorders is particularly high. The discussed markers of CVD risk in type 1 diabetes include apolipoproteins (apo-B and apo-C3), modified forms of LDL, and the role of high-density lipoprotein (HDL). Recently, a new look at the vasoprotective effect of HDL has appeared, which due to its dysfunctional form in type 1 diabetes may not protect against cardiovascular risk. The HDL proteome in type 1 diabetes has an altered protein composition compared to the healthy population. Another direction of research is determining the importance of trace elements (mainly Mg) in the development of diabetes complications.
糖尿病是一种影响全球许多人的疾病。其并发症是心血管疾病（CVD）和死亡率增加的原因。这就是为什么寻找预测生物标志物如此重要。本研究的目的是展示 1 型糖尿病儿童和青少年中该问题和危险因素的流行率。这些患者通常超重和肥胖，血脂紊乱的比例特别高。在 1 型糖尿病中讨论的 CVD 风险标志物包括载脂蛋白（apo-B 和 apo-C3）、修饰形式的 LDL 和高密度脂蛋白（HDL）的作用。最近，人们对 HDL 的血管保护作用有了新的认识，由于其在 1 型糖尿病中的功能失调形式，它可能无法预防心血管风险。与健康人群相比，1 型糖尿病中的 HDL 蛋白质组具有改变的蛋白质组成。另一个研究方向是确定微量元素（主要是镁）在糖尿病并发症发展中的重要性。
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