Rungby J, Ellermann-Eriksen S, Danscher G
Institute of Anatomy B, University of Aarhus, Denmark.
Arch Toxicol. 1987;61(1):40-5. doi: 10.1007/BF00324546.
The effects of selenium on cellular toxicity and histochemical distribution of silver were examined in a cell culture system of mouse peritoneal macrophages. Selenium caused a significant delay in the appearance of coagulation necrosis induced by high silver concentrations and reduced the cytostatic effect of lower doses of silver when long-term toxicity was examined. Furthermore, selenium increased the amount of silver that could be visualized by autometallography. The additional silver made available for this histochemical demonstration was located in the cytosol as well as in lysosomes, the sole localization of silver when selenium was not administered.
在小鼠腹腔巨噬细胞的细胞培养系统中，研究了硒对细胞毒性和银的组织化学分布的影响。当检测长期毒性时，硒显著延迟了高浓度银诱导的凝固性坏死的出现，并降低了低剂量银的细胞生长抑制作用。此外，硒增加了可通过自动金属显影法观察到的银的量。这种组织化学显示中额外可用的银位于细胞质以及溶酶体中，而在不给予硒时，银仅定位于溶酶体。
