工程蓝藻的最新进展及其在光合丁醇生产中的应用。
Current advances in engineering cyanobacteria and their applications for photosynthetic butanol production.
机构信息
Microbial Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 523, SE-751 20 Uppsala, Sweden.
Microbial Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Box 523, SE-751 20 Uppsala, Sweden.
出版信息
Curr Opin Biotechnol. 2022 Feb;73:143-150. doi: 10.1016/j.copbio.2021.07.014. Epub 2021 Aug 16.
Cyanobacteria are natural photosynthetic microbes which can be engineered for sustainable conversion of solar energy and carbon dioxide into chemical products. Attempts to improve target production often require an improved understanding of the native cyanobacterial host system. Valuable insights into cyanobacterial metabolism, biochemistry and physiology have been steadily increasing in recent years, stimulating key advancements of cyanobacteria as cell factories for biochemical, including biofuel, production. In the present review, we summarize the current progress in engineering cyanobacteria and discuss the achieved and potential utilization of these advances in cyanobacteria for the production of the bulk chemical butanol, specifically isobutanol and 1-butanol.
蓝藻是天然的光合作用微生物，可以通过工程设计将太阳能和二氧化碳可持续地转化为化学产品。为了提高目标产物的产量，通常需要更好地了解天然蓝藻宿主系统。近年来，人们对蓝藻的代谢、生物化学和生理学有了更深入的了解，这刺激了蓝藻作为生物化学（包括生物燃料）生产的细胞工厂的关键进展。在本综述中，我们总结了蓝藻工程的最新进展，并讨论了这些进展在蓝藻生产大宗化学品丁醇（特别是异丁醇和 1-丁醇）方面的已实现和潜在应用。
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