白血病中的氧化应激与抗氧化治疗。

Oxidative stress in leukemia and antioxidant treatment.

机构信息

Department of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.

Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.

出版信息

Chin Med J (Engl). 2021 Jul 12;134(16):1897-1907. doi: 10.1097/CM9.0000000000001628.

DOI:10.1097/CM9.0000000000001628

PMID:34415890

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8382483/

Abstract

Oxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.

摘要

氧化应激是由自由基/活性氧（ROS）的产生与抗氧化防御系统之间的失衡引起的，它可以激活各种转录因子并影响其转录途径。氧化应激在白血病的发生和发展中起着重要作用，与白血病的治疗和预后密切相关。白血病预处理的标准化疗策略存在许多缺点。因此，人们正在探索和初步应用抗氧化剂和氧化剂在白血病治疗中的应用。本文综述了氧化应激与白血病的研究进展。此外，还总结了抗氧化剂治疗在白血病中的应用。