百白破疫苗接种后出现低张-低反应性发作。
Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination.
机构信息
From the Kaiser Permanente Vaccine Study Center, Oakland, California.
Sanofi Pasteur, Swiftwater, Pennsylvania.
出版信息
Pediatr Infect Dis J. 2021 Dec 1;40(12):1122-1126. doi: 10.1097/INF.0000000000003308.
BACKGROUND
Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines.
METHODS
Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine.
RESULTS
We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children.
CONCLUSIONS
These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.
背景
全细胞百日咳疫苗接种后出现低张-低反应性发作（HHE）是一种已知的不良事件。关于接种无细胞百日咳疫苗后 HHE 的风险知之甚少。
方法
本研究通过父母访谈，主动调查了无细胞百日咳疫苗接种后第 1 剂和第 2 剂后婴儿的 HHE 情况。
结果
我们共采访了 52531 名婴儿的父母。无细胞百日咳疫苗的 HHE 发生率为每 10 万剂 22.8 例（95%CI：11.8-39.9），即每 10 万名儿童约发生 45 例 HHE。
结论
这些发生率低于全细胞百日咳疫苗报告的 HHE 发生率，且在其他无细胞百日咳疫苗研究报告的 HHE 发生率范围内。
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