用于牙科植入物的创新表面和合金：生物界面安全问题如何？
Innovative surfaces and alloys for dental implants: What about biointerface-safety concerns?
作者信息
Kunrath Marcel F, Muradás Thaís C, Penha Nilton, Campos Maria M
机构信息
Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil; Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Dent Mater. 2021 Oct;37(10):1447-1462. doi: 10.1016/j.dental.2021.08.008. Epub 2021 Aug 20.
OBJECTIVES
The present review article aimed to discuss the recent technologies employed for the development of dental implants, mainly regarding innovative surface treatments and alternative alloys, emphasizing the bio-tribocorrosion processes.
METHODS
An electronic search applying specific MeSH terms was carried out in PubMed and Google Scholar databases to collect data until August 2021, considering basic, pre-clinical, clinical and review studies. The relevant articles (n=111), focused on innovative surface treatments for dental implants and their potential undesirable biological effects, were selected and explored.
RESULTS
Novel texturization methodologies for dental implants clearly provided superficial and structural atomic alterations in micro- and nanoscale, promoting different mechanical-chemical interactions when applied in the clinical set. Some particulate metals released from implant surfaces, their degradation products and/or contaminants exhibited local and systemic reactions after implant installation and osseointegration, contributing to unexpected treatment drawbacks and adverse effects. Therefore, there is an urgent need for development of pre-clinical and clinical platforms for screening dental implant devices, to predict the biointerface reactions as early as possible during the development phases.
SIGNIFICANCE
Modern surface treatments and innovative alloys developed for dental implants are not completely understood regarding their integrity during long-term clinical function, especially when considering the bio-tribocorrosion process. From this review, it is possible to assume that degradation and contamination of dental surfaces might be associated within peri-implant inflammation and cumulative long-lasting systemic toxicity. The in-depth comprehension of the biointerface modifications on these novel surface treatments might preclude unnecessary expenses and postoperative complications involving osseointegration failures.
目的
本综述文章旨在讨论用于牙科植入物开发的最新技术，主要涉及创新的表面处理和替代合金，重点关注生物摩擦腐蚀过程。
方法
在PubMed和谷歌学术数据库中进行电子检索，应用特定的医学主题词来收集截至2021年8月的数据，纳入基础研究、临床前研究、临床研究和综述研究。筛选并探讨了111篇相关文章，这些文章聚焦于牙科植入物的创新表面处理及其潜在的不良生物学效应。
结果
牙科植入物的新型纹理化方法明显在微观和纳米尺度上提供了表面和结构的原子改变，在临床应用时促进了不同的机械化学相互作用。植入物表面释放的一些颗粒金属、其降解产物和/或污染物在植入和骨整合后表现出局部和全身反应，导致意外的治疗缺陷和不良反应。因此，迫切需要开发临床前和临床平台来筛选牙科植入物装置，以便在开发阶段尽早预测生物界面反应。
意义
为牙科植入物开发的现代表面处理和创新合金在长期临床功能期间的完整性尚未完全明了，尤其是考虑生物摩擦腐蚀过程时。从本综述可以推断，牙科表面的降解和污染可能与种植体周围炎症和累积的长期全身毒性有关。对这些新型表面处理的生物界面修饰的深入理解可能避免不必要的费用和涉及骨整合失败的术后并发症。
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