生物工程与生物技术前沿：用于抗癌治疗的植物纳米颗粒
Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy.
作者信息
Shoeb Erum, Badar Uzma, Venkataraman Srividhya, Hefferon Kathleen
机构信息
Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Department of Genetics, University of Karachi, Karachi 75270, Pakistan.
出版信息
Vaccines (Basel). 2021 Jul 28;9(8):830. doi: 10.3390/vaccines9080830.
Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.
天然存在的病毒纳米材料因其生物相容性和可生物降解性而受到欢迎。植物病毒纳米颗粒（VNPs）可作为纳米载体用于多种生物医学应用。植物VNPs生产成本低廉，给药安全且治疗有效。以下综述描述了植物病毒结构如何促进VNPs用于成像和各种治疗应用，尤其侧重于癌症。文中提供了经工程改造以携带针对特定类型癌症的药物和诊断剂的植物病毒实例。响应内部条件的药物递送系统被称为刺激响应，最近基于植物病毒的VNPs使其变得更适用。综述最后展望了植物VNPs和植物病毒样颗粒（VLPs）在癌症研究和治疗中的未来。
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