尿 N,N-二乙酰基精脒作为儿童癌症的生物标志物：一项病例对照研究。

Urinary N,N-diacetylspermine as a biomarker for pediatric cancer: a case-control study.

机构信息

Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa, Nagoya, 466-8550, Japan.

Department of Rare/Refractory Cancer Analysis Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Pediatr Surg Int. 2021 Dec;37(12):1659-1665. doi: 10.1007/s00383-021-04987-y. Epub 2021 Aug 28.

DOI:10.1007/s00383-021-04987-y

PMID:34453590

Abstract

PURPOSE

Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N,N-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer.

METHODS

Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared.

RESULTS

A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%).

CONCLUSION

The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.

摘要

目的

微创检查在儿科患者中尤为重要。虽然尿 N,N-二乙酰基精脒（DiAcSpm）作为肿瘤标志物（TM）在许多成人癌症中已有报道，但在儿科癌症中的应用尚未见报道。这可能是由于尿 DiAcSpm 水平随年龄变化。本研究旨在测量健康个体尿中 DiAcSpm 的正常水平，并探讨其作为儿童癌症 TM 的有用性。

方法

收集有和无癌症的儿科患者的尿样。测量尿 DiAcSpm 水平，并比较其值。

结果

本研究共纳入 32 例癌症患者和 405 例对照组。32 例患者中，神经母细胞瘤 13 例，恶性淋巴瘤（ML）9 例，白血病 10 例。在对照组中，尿 DiAcSpm 值在年龄较小的患者中波动较大，尤其是婴儿；而在大约 10 岁及以上的患者中，值趋于一致。DiAcSpm 的敏感性在三种癌症之间有显著差异：神经母细胞瘤（30.8%）、ML（77.8%）和白血病（40%）。