用于烧伤治疗的胶原生物塑料胶原蛋白材料。

Collost Bioplastic Collagen Material for the Treatment of Burns.

作者信息

Budkevich L I, Mirzoyan G V, Gabitov R B, Brazol M A, Salistyj P V, Chikinev Y V, Shmyrin A A, Glutkin A V

机构信息

Professor, Chief Researcher, Department of Combustiology and Reconstructive Plastic Surgery, Research Institute of Pediatric Surgery, Pirogov Russian National Research Medical University, 1 Ostrovitianova St., Moscow, 117997, Russia; Head of the Burn Center, Children's City Clinical Hospital No.9 named after G.N. Speransky, 29 Shmitovskiy Proezd, Moscow, 123317, Russia; Head of the 2 Burn Unit, Children's City Clinical Hospital No.9 named after G.N. Speransky, 29 Shmitovskiy Proezd, Moscow, 123317, Russia.

Pediatric Surgeon, the 2 Burn Unit, Children's City Clinical Hospital No.9 named after G.N. Speransky, 29 Shmitovskiy Proezd, Moscow, 123317, Russia.

出版信息

Sovrem Tekhnologii Med. 2020;12(1):92-96. doi: 10.17691/stm2020.12.1.12.

DOI:10.17691/stm2020.12.1.12

PMID:34513043

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8353710/

Abstract

UNLABELLED

was to evaluate the efficacy and safety of the Collost bioplastic material in the treatment of borderline and mosaic burns.

MATERIALS AND METHODS

We conducted a prospective multicenter study, which included 94 patients aged 1 to 12 years with thermal skin burns (grade II-III by ICD-10). Patients were divided into four groups. In groups 1-3, various forms of the Collost bioplastic material were used (group 1 - 7% gel, group 2 - membranes, group 3 - powder) in combination with hydrocolloid dressings containing Ag ions. Patients of the control group (group 4) underwent the traditional local conservative treatment using hydrocolloid dressings alone. Concomitant therapy was similar in all of the participating centers. The total follow-up period was 4 weeks from the date of burn injury.

RESULTS

On day 14, there were 23 cases (92%) of complete epithelization in group 1, 13 cases (68.4%) - in group 2, 21 cases (78%) - in group 3, and 9 cases (39.1%) - in group 4. The data from groups 1 and 3 significantly differed from those in control (p<0.05). The epithelialization of the burned skin in the Collost groups (7% gel and powder) was on average one week faster compared to the control.

CONCLUSION

The Collost bioplastic material (in the form of gel or powder) in combination with hydrocolloid dressings can be a functional and inexpensive alternative to autografts in the treatment of borderline and mosaic burns.

摘要

未标注

旨在评估Collost生物塑料材料治疗临界性和镶嵌性烧伤的疗效和安全性。

材料与方法

我们进行了一项前瞻性多中心研究，纳入94例1至12岁的皮肤热烧伤患者（根据ICD - 10为II - III级）。患者分为四组。在第1 - 3组中，使用了各种形式的Collost生物塑料材料（第1组 - 7%凝胶，第2组 - 膜，第3组 - 粉末），并与含银离子的水胶体敷料联合使用。对照组（第4组）患者仅使用水胶体敷料进行传统的局部保守治疗。所有参与中心的伴随治疗相似。从烧伤日期起的总随访期为4周。