miR-451在肺癌中的作用概述：诊断、治疗与预后

An Overview on the Role of miR-451 in Lung Cancer: Diagnosis, Therapy, and Prognosis.

作者信息

Soofiyani Saiedeh Razi, Hosseini Kamram, Soleimanian Alireza, Abkhooei Liela, Hoseini Akbar Mohammad, Tarhriz Vahideh, Ghasemnejad Tohid

机构信息

Clinical Research Development Unit of Sina Educational, Research and Treatment Center, Tabriz University of Medical Sciences, Tabriz,Iran | Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Student research committee, Shiraz University of Medical Sciences, Shiraz,Iran | Department of Molecular Medicine, Faculty of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Microrna. 2021;10(3):181-190. doi: 10.2174/2211536610666210910130828.

DOI:10.2174/2211536610666210910130828

PMID:34514995

Abstract

MicroRNAs (miRNAs) are highly conserved non-coding RNAs involved in many physiological processes such as cell proliferation, inhibition, development of apoptosis, differentiation, suppression of tumorigenicity, and regulation of cell growth. The description of the alterations of miRNA expression patterns in cancers will be helpful in recognizing biomarkers for early detection and possible therapeutic intervention in the treatment of cancers. Recent studies have shown that miR-451 is broadly dysregulated in lung cancer and is a crucial agent in lung tumor progression. This review summarizes recent advances in the potential role of miR-451 in lung cancer diagnosis, prognosis, and treatment and provides an insight into the potential use of miR-451 for the development of advanced therapeutic methods in lung cancer.

摘要

微小RNA（miRNA）是高度保守的非编码RNA，参与许多生理过程，如细胞增殖、抑制、凋亡发展、分化、肿瘤发生抑制以及细胞生长调控。对癌症中miRNA表达模式改变的描述将有助于识别早期检测的生物标志物以及癌症治疗中可能的治疗干预措施。最近的研究表明，miR-451在肺癌中广泛失调，是肺肿瘤进展的关键因素。本综述总结了miR-451在肺癌诊断、预后和治疗中的潜在作用的最新进展，并深入探讨了miR-451在肺癌先进治疗方法开发中的潜在用途。