Wang Zhenzhen, Hou Yuhan, Yao Zhen, Zhan Yanyan, Chen Wenyue, Liu Yulong
Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China.
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Dose Response. 2021 Sep 12;19(3):15593258211037127. doi: 10.1177/15593258211037127. eCollection 2021 Jul-Sep.
The relationship between interleukin-8 (IL-8) expression and the prognosis of gastric cancer (GC) patients has been reported, but the results are contradictory.
To investigate the effect of IL-8 expression on the prognosis of patients with GC.
A comprehensive search strategy was used to search the PubMed, Web of Science and Cochrane Library databases. The total survival time was analysed using the RevMan 5.4 software. Through extensive search and meta-analysis of relevant studies, studies examining the relationship between IL-8 expression and prognosis in patients with GC were conducted to obtain more accurate estimates.
Eight studies (1843 patients) were included. The combined results of all the studies showed that high expression of IL-8 was a risk factor for poor prognosis in patients with GC (hazard ratio (HR): 2.08; 95% CI: 1.81-2.39). Sensitivity analysis suggested that the pooled HR was stable, and omitting a single study did not change the significance of the pooled HR. Funnel plots revealed no significant publication bias in the meta-analysis.
High IL-8 expression could be a negative prognostic biomarker for patients with GC.
白细胞介素-8（IL-8）表达与胃癌（GC）患者预后的关系已有报道，但结果相互矛盾。
探讨IL-8表达对GC患者预后的影响。
采用全面检索策略检索PubMed、科学网和考克兰图书馆数据库。使用RevMan 5.4软件分析总生存时间。通过对相关研究进行广泛检索和荟萃分析，开展关于IL-8表达与GC患者预后关系的研究，以获得更准确的估计。
纳入8项研究（1843例患者）。所有研究的综合结果显示，IL-8高表达是GC患者预后不良的危险因素（风险比（HR）：2.08；95%置信区间：1.81 - 2.39）。敏感性分析表明合并的HR稳定，剔除单项研究不会改变合并HR的显著性。漏斗图显示荟萃分析中无显著的发表偏倚。
IL-8高表达可能是GC患者的不良预后生物标志物。
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