Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, Tsukuba, Japan.
Institute for Protein Research, Osaka University, Suita, Japan.
Neuropsychopharmacol Rep. 2021 Dec;41(4):526-531. doi: 10.1002/npr2.12209. Epub 2021 Sep 20.
Acute N-methyl-D-aspartate (NMDA) receptor antagonism is an important pharmacological animal model of schizophrenia. In previous studies, schizophrenia patients show impaired goal-directed behavior in an outcome-specific devaluation procedure. In this study, we investigated whether the rat model of the NMDA receptor blockade also showed altered goal-directed behavior in a satiety-induced outcome devaluation paradigm.
In experiments 1 and 2, we aimed to establish the satiety-induced outcome devaluation test using sucrose and lipid rewards in operant conditioning and free consumption paradigms. In experiment 3, we tested the effect of MK-801 (0.1 mg/kg, i.p.) on outcome-specific devaluation.
Experiments 1 and 2 demonstrated that 1-h ad libitum food consumption is sufficient to induce outcome-specific devaluation in both lever-press and free consumption tests in rats. Experiment 3 showed that the administration of MK-801 impaired satiety-induced devaluation in the lever-press test but not in the subsequent free consumption test.
Our results suggest that acute pharmacological NMDA receptor antagonism in rats is a useful animal model for impaired goal-directed behavior in schizophrenia.
急性 N-甲基-D-天冬氨酸（NMDA）受体拮抗作用是精神分裂症的一种重要药理学动物模型。在以前的研究中，精神分裂症患者在特定结果的价值贬低程序中表现出目标导向行为受损。在这项研究中，我们研究了 NMDA 受体阻断的大鼠模型是否也在饱腹感诱导的结果贬低范式中表现出改变的目标导向行为。
在实验 1 和 2 中，我们旨在使用蔗糖和脂质奖励在操作性条件反射和自由消费范式中建立饱腹感诱导的结果贬低测试。在实验 3 中，我们测试了 MK-801（0.1 mg/kg，i.p.）对特定结果的价值贬低的影响。
实验 1 和 2 表明，1 小时的自由食物摄入足以在大鼠的杠杆按压和自由消费测试中引起特定结果的价值贬低。实验 3 表明，MK-801 的给药会损害杠杆按压测试中的饱腹感诱导的价值贬低，但不会在随后的自由消费测试中产生影响。
我们的结果表明，急性药理学 NMDA 受体拮抗作用在大鼠中是精神分裂症中目标导向行为受损的有用动物模型。
